Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Complementary use of cross-polarization and standard OCT for differential diagnosis of pathological tissues
Roman V. Kuranov,V. V. Sapozhnikova,Ilya V. Turchin,E. V. Zagainova,Valentin M. Gelikonov,Vladislav A. Kamensky,Ludmila B. Snopova,Natalia N. Prodanetz +7 more
TL;DR: It is shown that healthy, neoplastic and scar tissues of the esophagus have different cross-polarization backscattering properties, which improves the specificity of diagnostics of pathological changes occurring in tissues.
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Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization
Martin F. Kraus,Jonathan J. Liu,Julia Schottenhamml,Chieh-Li Chen,Attila Budai,Lauren Branchini,Tony H. Ko,Hiroshi Ishikawa,Gadi Wollstein,Joel S. Schuman,Jay S. Duker,James G. Fujimoto,Joachim Hornegger +12 more
TL;DR: The quantitative results consistently show that reproducibility is improved considerably by using the advanced algorithm, which also significantly outperforms the basic algorithm, and demonstrates that the advanced motion correction algorithm has the potential to improve the reliability of quantitative measurements derived from 3D-OCT data substantially.
Journal ArticleDOI
Simultaneous B-M-mode scanning method for real-time full-range Fourier domain optical coherence tomography
TL;DR: High-speed complex full-range Fourier domain optical coherence tomography (FD-OCT) is demonstrated, which investigates a sweat duct in a finger pad in vivo and visualizes it with an acquisition time of 27 ms.
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Optical coherence tomography as a method for identifying benign and malignant microscopic structures in the prostate gland
TL;DR: Microscopic resolution is possible in human prostatic tissue using OCT and further studies using this technique to improve the detection and staging of adenocarcinoma of the prostate are ongoing.
Journal ArticleDOI
Low-coherence optical tomography in turbid tissue: theoretical analysis
TL;DR: Theoretical analyses and preliminary experimental results suggest that, unlike time-resolving spectroscopy, low-coherence optical tomography detects the local relative variations of path-length-resolved reflectance from the turbid tissues.
References
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