The genetics of Mexico recapitulates Native American substructure and affects biomedical traits
Andrés Moreno-Estrada,Christopher R. Gignoux,Juan Carlos Fernández-López,Fouad Zakharia,Martin Sikora,Alejandra V. Contreras,Victor Acuña-Alonzo,Karla Sandoval,Celeste Eng,Sandra Romero-Hidalgo,Patricia Ortiz-Tello,Victoria Robles,Eimear E. Kenny,Ismael Nuño-Arana,Rodrigo Barquera-Lozano,Gastón Macín-Pérez,Julio Granados-Arriola,Scott Huntsman,Joshua Galanter,Marc Via,Jean G. Ford,Rocio Chapela,William Rodriguez-Cintron,J.R. Rodriguez-Santana,Isabelle Romieu,Juan José Luis Sienra-Monge,Blanca E. del Rio Navarro,Stephanie J. London,Andres Ruiz-Linares,Rodrigo García-Herrera,Karol Estrada,Alfredo Hidalgo-Miranda,Gerardo Jimenez-Sanchez,Alessandra Carnevale,Xavier Soberón,Samuel Canizales-Quinteros,Héctor Rangel-Villalobos,Irma Silva-Zolezzi,Esteban G. Burchard,Carlos Bustamante +39 more
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TLDR
Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country, and two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function.Abstract:
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.read more
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Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry.
Carlos Iribarren,Meng Lu,Eric Jorgenson,Manuel Martinez,Carla Lluis-Ganella,Isaac Subirana,Eduardo Salas,Roberto Elosua +7 more
TL;DR: The clinical utility of two multi-locus genetic risk scores previously validated in Europeans among persons of African, Latino, Latino and East-Asian ancestry is examined and support the usefulness of incorporating genetic information into risk assessment for primary prevention among minority subjects in the U.S.
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Comparing ethnicity-based and expanded carrier screening methods at a single fertility center reveals significant differences in carrier rates and carrier couple rates.
Alexandra Peyser,T. Singer,Christine Mullin,Sara L. Bristow,Amber Gamma,Kenan Onel,Kenan Onel,A. Hershlag +7 more
TL;DR: It is proposed that all reproductive-aged women should be offered ECS, and carrier couple rates would likely increase further with expansion of the panel, playing a pivotal role in preventing genetic disease in fertility clinics.
Journal ArticleDOI
Archaeogenomic distinctiveness of the Isthmo-Colombian area
Marco Rosario Capodiferro,Bethany Aram,Alessandro Raveane,Alessandro Raveane,Nicola Rambaldi Migliore,Giulia Colombo,Linda Ongaro,Javier Rivera,Tomás Mendizábal,Iosvany Hernández-Mora,Maribel Tribaldos,Ugo A. Perego,Hongjie Li,Christiana L. Scheib,Alessandra Modi,Alberto Gómez-Carballa,Viola Grugni,Gianluca Lombardo,Garrett Hellenthal,Juan Miguel Pascale,Francesco Bertolini,Gaetano S. Grieco,Cristina Cereda,Martina Lari,David Caramelli,Luca Pagani,Luca Pagani,Mait Metspalu,Ronny Friedrich,Corina Knipper,Anna Olivieri,Antonio Salas,Richard G. Cooke,Richard G. Cooke,Francesco Montinaro,Francesco Montinaro,Jorge Motta,Antonio Torroni,Juan Guillermo Martín,Ornella Semino,Ripan S. Malhi,Alessandro Achilli +41 more
TL;DR: In this paper, the authors report ten pre-Hispanic (plus two early colonial) genomes and 84 genome-wide profiles from seven groups presently living in Panama and reveal that demographic events contributed to the extensive genetic structure currently seen in the area, which is also characterized by a distinctive Isthmo-colombian Indigenous component.
Journal ArticleDOI
The Effect of Ancestry and Genetic Variation on Lung Function Predictions: What Is “Normal” Lung Function in Diverse Human Populations?
TL;DR: The potential limitations of current lung function reference equations in a global society which is becoming more ethnically, racially, and, thus, genetically diverse are discussed and how an individual's ancestral background or genetic profile could provide the basis for more accurate, personalized predictions of an individual’s baseline lung function is discussed.
Journal ArticleDOI
Genetic Resources in the "Calabaza Pipiana" Squash (Cucurbita argyrosperma) in Mexico: Genetic Diversity, Genetic Differentiation and Distribution Models.
Guillermo Sánchez-de la Vega,Gabriela Castellanos-Morales,Niza Gámez,Helena S. Hernández-Rosales,Alejandra Vázquez-Lobo,Alejandra Vázquez-Lobo,Erika Aguirre-Planter,Juan P. Jaramillo-Correa,Salvador Montes-Hernández,Rafael Lira-Saade,Luis E. Eguiarte +10 more
TL;DR: The main aim of this study was to use molecular data to assess the levels of genetic variation and genetic differentiation within and among populations of domesticated argyrosperma across its distribution in Mexico in comparison to its wild relative, sororia, and to identify environmental suitability in previously proposed centers of domestication.
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