Å
Åsa K. Hedman
Researcher at Karolinska Institutet
Publications - 61
Citations - 11302
Åsa K. Hedman is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: DNA methylation & Genome-wide association study. The author has an hindex of 31, co-authored 52 publications receiving 9886 citations. Previous affiliations of Åsa K. Hedman include Wellcome Trust & University of Oxford.
Papers
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Genetic studies of body mass index yield new insights for obesity biology
Adam E. Locke,Bratati Kahali,Sonja I. Berndt,Anne E. Justice,Tune H. Pers,Felix R. Day,Corey Powell,Sailaja Vedantam,Martin L. Buchkovich,Jian Yang,Damien C. Croteau-Chonka,Tõnu Esko,Tove Fall,Teresa Ferreira,Stefan Gustafsson,Zoltán Kutalik,Jian'an Luan,Reedik Mägi,Joshua C. Randall,Thomas W. Winkler,Andrew R. Wood,Tsegaselassie Workalemahu,Jessica D. Faul,Jennifer A. Smith,Jing Hua Zhao,Wei Zhao,Jin Chen,Rudolf S N Fehrmann,Åsa K. Hedman,Juha Karjalainen,Ellen M. Schmidt,Devin Absher,Najaf Amin,Denise Anderson,Marian Beekman,Jennifer L. Bolton,Jennifer L. Bragg-Gresham,Steven Buyske,Ayse Demirkan,Guohong Deng,Georg Ehret,Bjarke Feenstra,Mary F. Feitosa,Krista Fischer,Anuj Goel,Jian Gong,Anne U. Jackson,Stavroula Kanoni,Marcus E. Kleber,Kati Kristiansson,Unhee Lim,Vaneet Lotay,Massimo Mangino,Irene Mateo Leach,Carolina Medina-Gomez,Sarah E. Medland,Mike A. Nalls,Cameron D. Palmer,Dorota Pasko,Sonali Pechlivanis,Marjolein Peters,Inga Prokopenko,Dmitry Shungin,Alena Stančáková,Rona J. Strawbridge,Yun Ju Sung,Toshiko Tanaka,Alexander Teumer,Stella Trompet,Sander W. van der Laan,Jessica van Setten,Jana V. van Vliet-Ostaptchouk,Zhaoming Wang,Loic Yengo,Weihua Zhang,Aaron Isaacs,Eva Albrecht,Johan Ärnlöv,Gillian M. Arscott,Antony P. Attwood,Stefania Bandinelli,Amy Barrett,Isabelita Bas,Claire Bellis,Amanda J. Bennett,Christian Berne,Roza Blagieva,Matthias Blüher,Stefan Böhringer,Lori L. Bonnycastle,Yvonne Böttcher,Heather A. Boyd,Marcel Bruinenberg,Ida Henriette Caspersen,Yii-Der Ida Chen,Robert Clarke,E. Warwick Daw,Anton J. M. de Craen,Graciela E. Delgado,Maria Dimitriou,Alex S. F. Doney,Niina Eklund,Karol Estrada,Elodie Eury,Lasse Folkersen,Ross M. Fraser,Melissa E. Garcia,Frank Geller,Vilmantas Giedraitis,Bruna Gigante,Alan S. Go,Alain Golay,Alison H. Goodall,Scott D. Gordon,Mathias Gorski,Hans-Jörgen Grabe,Harald Grallert,Tanja B. Grammer,Jürgen Gräßler,Henrik Grönberg,Christopher J. Groves,Gaëlle Gusto,Jeffrey Haessler,Per Hall,Toomas Haller,Göran Hallmans,Catharina A. Hartman,Maija Hassinen,Caroline Hayward,Nancy L. Heard-Costa,Quinta Helmer,Christian Hengstenberg,Oddgeir L. Holmen,Jouke-Jan Hottenga,Alan James,Janina M. Jeff,Åsa Johansson,Jennifer Jolley,Thorhildur Juliusdottir,Leena Kinnunen,Wolfgang Koenig,Markku Koskenvuo,Wolfgang Kratzer,Jaana Laitinen,Claudia Lamina,Karin Leander,Nanette R. Lee,Peter Lichtner,Lars Lind,Jaana Lindström,Ken Sin Lo,Stéphane Lobbens,Roberto Lorbeer,Yingchang Lu,François Mach,Patrik K. E. Magnusson,Anubha Mahajan,Wendy L. McArdle,Stela McLachlan,Cristina Menni,Sigrun Merger,Evelin Mihailov,Lili Milani,Alireza Moayyeri,Keri L. Monda,Mario A. Morken,Antonella Mulas,Gabriele Müller,Martina Müller-Nurasyid,Arthur W. Musk,Ramaiah Nagaraja,Markus M. Nöthen,Ilja M. Nolte,Stefan Pilz,Nigel W. Rayner,Frida Renström,Rainer Rettig,Janina S. Ried,Stephan Ripke,Neil R. Robertson,Lynda M. Rose,Serena Sanna,Hubert Scharnagl,Salome Scholtens,Fredrick R. Schumacher,William R. Scott,Thomas Seufferlein,Jianxin Shi,Albert V. Smith,Joanna Smolonska,Alice Stanton,Valgerdur Steinthorsdottir,Kathleen Stirrups,Heather M. Stringham,Johan Sundström,Morris A. Swertz,Amy J. Swift,Ann-Christine Syvänen,Sian-Tsung Tan,Bamidele O. Tayo,Barbara Thorand,Gudmar Thorleifsson,Jonathan Tyrer,Hae-Won Uh,Liesbeth Vandenput,Frank C. Verhulst,Sita H. Vermeulen,Niek Verweij,Judith M. Vonk,Lindsay L. Waite,Helen R. Warren,Dawn M. Waterworth,Michael N. Weedon,Lynne R. Wilkens,Christina Willenborg,Tom Wilsgaard,Mary K. Wojczynski,Andrew Wong,Alan F. Wright,Qunyuan Zhang,Eoin P. Brennan,Murim Choi,Zari Dastani,Alexander W. Drong,Per Eriksson,Anders Franco-Cereceda,Jesper R. Gådin,Ali G. Gharavi,Michael E. Goddard,Robert E. Handsaker,Jinyan Huang,Fredrik Karpe,Sekar Kathiresan,Sarah Keildson,Krzysztof Kiryluk,Michiaki Kubo,Jong-Young Lee,Liming Liang,Richard P. Lifton,Baoshan Ma,Steven A. McCarroll,Amy Jayne McKnight,Josine L. Min,Miriam F. Moffatt,Grant W. Montgomery,Joanne M. Murabito,George Nicholson,Dale R. Nyholt,Yukinori Okada,John R. B. Perry,Rajkumar Dorajoo,Eva Reinmaa,Rany M. Salem,Niina Sandholm,Robert A. Scott,Lisette Stolk,Atsushi Takahashi,Toshihiro Tanaka,Ferdinand M. van't Hooft,Anna A. E. Vinkhuyzen,Harm-Jan Westra,Wei Zheng,Krina T. Zondervan,Andrew C. Heath,Dominique Arveiler,Stephan J. L. Bakker,John Beilby,Richard N. Bergman,John Blangero,Pascal Bovet,Harry Campbell,Mark J. Caulfield,Giancarlo Cesana,Aravinda Chakravarti,Daniel I. Chasman,Peter S. Chines,Francis S. Collins,Dana C. Crawford,L. Adrienne Cupples,Daniele Cusi,John Danesh,Ulf de Faire,Hester M. den Ruijter,Anna F. Dominiczak,Raimund Erbel,Jeanette Erdmann,Johan G. Eriksson,Martin Farrall,Stephan B. Felix,Ele Ferrannini,Jean Ferrières,Ian Ford,Nita G. Forouhi,Terrence Forrester,Oscar H. Franco,Ron T. Gansevoort,Pablo V. Gejman,Christian Gieger,Omri Gottesman,Vilmundur Gudnason,Ulf Gyllensten,Alistair S. Hall,Tamara B. Harris,Andrew T. Hattersley,Andrew A. Hicks,Lucia A. Hindorff,Aroon D. Hingorani,Albert Hofman,Georg Homuth,G. Kees Hovingh,Steve E. Humphries,Steven C. Hunt,Elina Hyppönen,Thomas Illig,Kevin B. Jacobs,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Berit Johansen,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Jaakko Kaprio,John J.P. Kastelein,Sirkka Keinänen-Kiukaanniemi,Lambertus A. Kiemeney,Paul Knekt,Jaspal S. Kooner,Charles Kooperberg,Peter Kovacs,Aldi T. Kraja,Meena Kumari,Johanna Kuusisto,Timo A. Lakka,Claudia Langenberg,Loic Le Marchand,Terho Lehtimäki,Valeriya Lyssenko,Satu Männistö,André Marette,Tara C. Matise,Colin A. McKenzie,Barbara McKnight,Frans L. Moll,Andrew D. Morris,Andrew P. Morris,Jeffrey C. Murray,Mari Nelis,Claes Ohlsson,Albertine J. Oldehinkel,Ken K. Ong,Pamela A. F. Madden,Gerard Pasterkamp,John F. Peden,Annette Peters,Dirkje S. Postma,Peter P. Pramstaller,Jackie F. Price,Lu Qi,Olli T. Raitakari,Tuomo Rankinen,Dabeeru C. Rao,Treva Rice,Paul M. Ridker,John D. Rioux,Marylyn D. Ritchie,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Jouko Saramies,Mark A. Sarzynski,Heribert Schunkert,Peter Schwarz,Peter S. Sever,Alan R. Shuldiner,Juha Sinisalo,Ronald P. Stolk,Konstantin Strauch,Anke Tönjes,David-Alexandre Trégouët,Angelo Tremblay,Elena Tremoli,Jarmo Virtamo,Marie-Claude Vohl,Uwe Völker,Gérard Waeber,Gonneke Willemsen,Jacqueline C. M. Witteman,M. Carola Zillikens,Linda S. Adair,Philippe Amouyel,Folkert W. Asselbergs,Themistocles L. Assimes,Murielle Bochud,Bernhard O. Boehm,Eric Boerwinkle,Stefan R. Bornstein,Erwin P. Bottinger,Claude Bouchard,Stéphane Cauchi,John C. Chambers,Stephen J. Chanock,Richard S. Cooper,Paul I.W. de Bakker,George Dedoussis,Luigi Ferrucci,Paul W. Franks,Philippe Froguel,Leif Groop,Christopher A. Haiman,Anders Hamsten,Jennie Hui,David J. Hunter,Kristian Hveem,Robert C. Kaplan,Mika Kivimäki,Diana Kuh,Markku Laakso,Yongmei Liu,Nicholas G. Martin,Winfried März,Mads Melbye,Andres Metspalu,Susanne Moebus,Patricia B. Munroe,Inger Njølstad,Ben A. Oostra,Colin N. A. Palmer,Nancy L. Pedersen,Markus Perola,Louis Pérusse,Ulrike Peters,Chris Power,Thomas Quertermous,Rainer Rauramaa,Fernando Rivadeneira,Timo Saaristo,Danish Saleheen,Naveed Sattar,Eric E. Schadt,David Schlessinger,P. Eline Slagboom,Harold Snieder,Tim D. Spector,Unnur Thorsteinsdottir,Michael Stumvoll,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Pim van der Harst,Mark Walker,Henri Wallaschofski,Nicholas J. Wareham,Hugh Watkins,David R. Weir,H-Erich Wichmann,James F. Wilson,Pieter Zanen,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Iris M. Heid,Jeffrey R. O'Connell,David P. Strachan,Kari Stefansson,Cornelia M. van Duijn,Gonçalo R. Abecasis,Lude Franke,Timothy M. Frayling,Mark I. McCarthy,Peter M. Visscher,André Scherag,Cristen J. Willer,Michael Boehnke,Karen L. Mohlke,Cecilia M. Lindgren,Jacques S. Beckmann,Inês Barroso,Kari E. North,Erik Ingelsson,Joel N. Hirschhorn,Ruth J. F. Loos,Elizabeth K. Speliotes +481 more
TL;DR: This paper conducted a genome-wide association study and meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals.
Journal ArticleDOI
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Anubha Mahajan,Min Jin Go,Weihua Zhang,Jennifer E. Below,Kyle J. Gaulton,Teresa Ferreira,Momoko Horikoshi,Andrew D. Johnson,Maggie C.Y. Ng,Inga Prokopenko,Inga Prokopenko,Danish Saleheen,Xu Wang,Eleftheria Zeggini,Gonçalo R. Abecasis,Linda S. Adair,Peter Almgren,Mustafa Atalay,Tin Aung,Tin Aung,Damiano Baldassarre,Beverley Balkau,Beverley Balkau,Yuqian Bao,Anthony H. Barnett,Anthony H. Barnett,Inês Barroso,Inês Barroso,Inês Barroso,Abdul Basit,Latonya F. Been,John Beilby,John Beilby,Graeme I. Bell,Rafn Benediktsson,Richard N. Bergman,Bernhard OBoehm,Bernhard OBoehm,Eric Boerwinkle,Eric Boerwinkle,Lori L. Bonnycastle,Noël P. Burtt,Qiuyin Cai,Harry Campbell,Jason Carey,Stéphane Cauchi,Mark J. Caulfield,Juliana C.N. Chan,Li Ching Chang,Tien-Jyun Chang,Yi-Cheng Chang,Guillaume Charpentier,Chien-Hsiun Chen,Chien-Hsiun Chen,Han Chen,Yuan-Tsong Chen,Kee Seng Chia,Manickam Chidambaram,Peter S. Chines,Nam H. Cho,Young Min Cho,Lee-Ming Chuang,Francis S. Collins,Marilyn C. Cornelis,David Couper,Andrew Crenshaw,Rob M. van Dam,Rob M. van Dam,John Danesh,Debashish Das,Ulf de Faire,George Dedoussis,Panos Deloukas,Antigone S. Dimas,Christian Dina,Christian Dina,Alex S. F. Doney,Peter Donnelly,Mozhgan Dorkhan,Cornelia M. van Duijn,Josée Dupuis,Josée Dupuis,Sarah Edkins,Paul Elliott,Paul Elliott,Valur Emilsson,Raimund Erbel,Johan G. Eriksson,Jorge Escobedo,Tõnu Esko,Tõnu Esko,Elodie Eury,Jose C. Florez,Jose C. Florez,Pierre Fontanillas,Nita G. Forouhi,Tom Forsén,Caroline S. Fox,Caroline S. Fox,Ross M. Fraser,Timothy M. Frayling,Philippe Froguel,Philippe Froguel,Philippe M. Frossard,Yu-Tang Gao,Karl Gertow,Christian Gieger,Bruna Gigante,Harald Grallert,George B. Grant,Leif Groop,Christopher J. Groves,Elin Grundberg,Elin Grundberg,Elin Grundberg,Candace Guiducci,Anders Hamsten,Bok Ghee Han,Hara Kazuo,Neelam Hassanali,Andrew T. Hattersley,Caroline Hayward,Åsa K. Hedman,Christian Herder,Albert Hofman,Oddgeir L. Holmen,Kees Hovingh,Astradur B. Hreidarsson,Cheng Hu,Frank B. Hu,Jennie Hui,Jennie Hui,Steve E. Humphries,Sarah E. Hunt,David J. Hunter,Kristian Hveem,Zafar I. Hydrie,Hiroshi Ikegami,Thomas Illig,Erik Ingelsson,Erik Ingelsson,Muhammed Islam,Bo Isomaa,Anne U. Jackson,Tazeen H. Jafar,Alan James,Alan James,Weiping Jia,Karl-Heinz Jöckel,Anna Jonsson,Jeremy B M Jowett,Takashi Kadowaki,Hyun Min Kang,Stavroula Kanoni,Wen Hong L. Kao,Sekar Kathiresan,Sekar Kathiresan,Norihiro Kato,Prasad Katulanda,Prasad Katulanda,Sirkka Keinänen-Kiukaanniemi,Ann M. Kelly,Ann M. Kelly,Hassan Khan,Kay-Tee Khaw,Chiea Chuen Khor,Chiea Chuen Khor,Chiea Chuen Khor,Hyung Lae Kim,Sangsoo Kim,Young Jin Kim,Leena Kinnunen,Norman Klopp,Augustine Kong,Eeva Korpi-Hyövälti,Sudhir Kowlessur,Peter Kraft,Jasmina Kravic,Malene M. Kristensen,S. Krithika,Ashok Kumar,Jesús Kumate,Johanna Kuusisto,Soo Heon Kwak,Markku Laakso,Vasiliki Lagou,Timo A. Lakka,Claudia Langenberg,Cordelia Langford,Robert W. Lawrence,Karin Leander,Jen Mai Lee,Nanette R. Lee,Man Li,Xinzhong Li,Yun Li,Junbin Liang,Samuel Liju,Wei-Yen Lim,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Eero Lindholm,Ching-Ti Liu,Jianjun Liu,Stéphane Lobbens,Jirong Long,Ruth J. F. Loos,Ruth J. F. Loos,Wei Lu,Jian'an Luan,Valeriya Lyssenko,Ronald C. WMa,Shiro Maeda,Reedik Mägi,Satu Männistö,David R. Matthews,James B. Meigs,James B. Meigs,Olle Melander,Andres Metspalu,Julia Meyer,Ghazala Mirza,Evelin Mihailov,Susanne Moebus,Viswanathan Mohan,Viswanathan Mohan,Karen L. Mohlke,Andrew D. Morris,Thomas WMühleisen,Martina Müller-Nurasyid,Martina Müller-Nurasyid,Bill Musk,Bill Musk,Jiro Nakamura,Eitaro Nakashima,Pau Navarro,Peng Keat Ng,Alexandra C. Nica,Peter M. Nilsson,Inger Njølstad,Markus M. Nöthen,Keizo Ohnaka,Twee Hee Ong,Katharine R. Owen,Colin N. A. Palmer,James S. Pankow,Kyong Soo Park,Melissa Parkin,Sonali Pechlivanis,Nancy L. Pedersen,Leena Peltonen,John R. B. Perry,John R. B. Perry,Annette Peters,Janani Pinidiyapathirage,Carl G. P. Platou,Simon C. Potter,Jackie F. Price,Lu Qi,Venkatesan Radha,Loukianos S. Rallidis,Asif Rasheed,Wolfgang Rathmann,Rainer Rauramaa,Soumya Raychaudhuri,N. William Rayner,Simon D. Rees,Simon D. Rees,Emil Rehnberg,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Neil Robertson,Michael Roden,Elizabeth J. Rossin,Elizabeth J. Rossin,Elizabeth J. Rossin,Igor Rudan,Denis Rybin,Timo Saaristo,Veikko Salomaa,Juha Saltevo,Maria Samuel,Dharambir KSanghera,Jouko Saramies,James Scott,Laura J. Scott,Robert A. Scott,Ayellet V. Segrè,Ayellet V. Segrè,Joban Sehmi,Joban Sehmi,Bengt Sennblad,Nabi Shah,Sonia Shah,A. Samad Shera,Xiao-Ou Shu,Alan R. Shuldiner,Gunnar Sigurosson,Eric J.G. Sijbrands,Angela Silveira,Xueling Sim,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Kerrin S. Small,Wing-Yee So,Alena Stančáková,Kari Stefansson,Kari Stefansson,Gerald Steinbach,Valgerdur Steinthorsdottir,Kathleen Stirrups,Rona J. Strawbridge,Heather M. Stringham,Qi Sun,Chen Suo,Ann-Christine Syvänen,Ryoichi Takayanagi,Fumihiko Takeuchi,Wan Ting Tay,Tanya M. Teslovich,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Emmi Tikkanen,Emmi Tikkanen,Joseph Trakalo,Elena Tremoli,Mieke D. Trip,Fuu Jen Tsai,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Adan Valladares-Salgado,Sailaja Vedantam,Sailaja Vedantam,Fabrizio Veglia,Benjamin F. Voight,Benjamin F. Voight,Congrong Wang,Nicholas J. Wareham,Roman Wennauer,Ananda R. Wickremasinghe,Tom Wilsgaard,James F. Wilson,S Wiltshire,Wendy Winckler,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Andrew R. Wood,Jer-Yuarn Wu,Jer-Yuarn Wu,Ying Wu,Ken Yamamoto,Toshimasa Yamauchi,Mingyu Yang,Loic Yengo,Mitsuhiro Yokota,Robin Young,Delilah Zabaneh,Fan Zhang,Rong Zhang,Wei Zheng,Paul Zimmet,David Altshuler,David Altshuler,Donald W. Bowden,Donald W. Bowden,Yoon Shin Cho,Nancy J. Cox,Miguel Cruz,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Jong-Young Lee,Mark Seielstad,Mark Seielstad,Mark Seielstad,Yik Ying Teo,Yik Ying Teo,Michael Boehnke,Esteban J. Parra,John C. Chambers,John C. Chambers,John C. Chambers,E. Shyong Tai,Mark I. McCarthy,Andrew P. Morris,Andrew P. Morris +395 more
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
Journal ArticleDOI
Mapping cis - and trans -regulatory effects across multiple tissues in twins
Elin Grundberg,Kerrin S. Small,Kerrin S. Small,Åsa K. Hedman,Alexandra C. Nica,Alfonso Buil,Sarah Keildson,Jordana T. Bell,Jordana T. Bell,Yang T-P.,Eshwar Meduri,Eshwar Meduri,Amy Barrett,James Nisbett,Magdalena Sekowska,Alicja Wilk,Shin S-Y.,Daniel Glass,Mary E. Travers,Josine L. Min,Susan M. Ring,Karen M Ho,Gudmar Thorleifsson,Augustine Kong,Unnur Thorsteindottir,Unnur Thorsteindottir,Chrysanthi Ainali,Antigone S. Dimas,Neelam Hassanali,Catherine E. Ingle,David A. Knowles,Maria Krestyaninova,Christopher E. Lowe,Christopher E. Lowe,P. Di Meglio,Stephen B. Montgomery,Stephen B. Montgomery,Leopold Parts,Simon C. Potter,Gabriela L. Surdulescu,Loukia Tsaprouni,Sophia Tsoka,Veronique Bataille,Richard Durbin,Frank O. Nestle,Stephen O'Rahilly,Stephen O'Rahilly,Nicole Soranzo,Cecilia M. Lindgren,Krina T. Zondervan,Kourosh R. Ahmadi,Eric E. Schadt,Kari Stefansson,Kari Stefansson,George Davey Smith,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Panos Deloukas,Emmanouil T. Dermitzakis,Tim D. Spector +60 more
TL;DR: It is shown that at least 40% of the total heritable cis effect on expression cannot be accounted for by common cis variants, a finding that reveals the contribution of low-frequency and rare regulatory variants with respect to both transcriptional regulation and complex trait susceptibility.
Journal ArticleDOI
Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
Jordana T. Bell,Pei-Chien Tsai,Tsun-Po Yang,Ruth Pidsley,James Nisbet,Daniel Glass,Massimo Mangino,Guangju Zhai,Guangju Zhai,Feng Zhang,Ana M. Valdes,So-Youn Shin,Emma Dempster,Robin M. Murray,Elin Grundberg,Elin Grundberg,Åsa K. Hedman,Alexandra C. Nica,Kerrin S. Small,Emmanouil T. Dermitzakis,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Jonathan Mill,Tim D. Spector,Panos Deloukas +25 more
TL;DR: The results suggest that in a small set of genes DNA methylation may be a candidate mechanism of mediating not only environmental, but also genetic effects on age-related phenotypes, and that a-DMRs may initiate at an earlier age.
Journal ArticleDOI
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
Yoon Shin Cho,Chien Hsiun Chen,Chien Hsiun Chen,Cheng Hu,Jirong Long,Rick Twee-Hee Ong,Xueling Sim,Fumihiko Takeuchi,Ying Wu,Min Jin Go,Toshimasa Yamauchi,Yi-Cheng Chang,Soo Heon Kwak,Ronald C.W. Ma,Ken Yamamoto,Linda S. Adair,Tin Aung,Qiuyin Cai,Li Ching Chang,Yuan-Tsong Chen,Yu-Tang Gao,Frank B. Hu,Hyung Lae Kim,Sangsoo Kim,Young-Jin Kim,Jeannette Lee,Nanette R. Lee,Yun Li,Jianjun Liu,Wei Lu,Jiro Nakamura,Eitaro Nakashima,Daniel P.K. Ng,Wan Ting Tay,Fuu Jen Tsai,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Mitsuhiro Yokota,Wei Zheng,Rong Zhang,Congrong Wang,Wing-Yee So,Keizo Ohnaka,Hiroshi Ikegami,Hara Kazuo,Young Min Cho,Nam H. Cho,Tien-Jyun Chang,Yuqian Bao,Åsa K. Hedman,Andrew P. Morris,Mark I. McCarthy,Ryoichi Takayanagi,Kyong Soo Park,Weiping Jia,Lee-Ming Chuang,Juliana C.N. Chan,Shiro Maeda,Takashi Kadowaki,Jong-Young Lee,Jer-Yuarn Wu,Jer-Yuarn Wu,Yik Ying Teo,Yik Ying Teo,E. Shyong Tai,Xiao-Ou Shu,Karen L. Mohlke,Norihiro Kato,Bok Ghee Han,Mark Seielstad,Mark Seielstad,Mark Seielstad +72 more
TL;DR: The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3, which may regulate glucose-dependent insulin secretion in the pancreas.