Gadjah Mada University

About: Gadjah Mada University is a education organization based out in Yogyakarta, Indonesia. It is known for research contribution in the topics: Population & Adsorption. The organization has 17307 authors who have published 21389 publications receiving 116561 citations. The organization is also known as: University of Gajah Mada & Universitas Gadjah Mada.

Potential vulnerability implications of coastal inundation due to sea level rise for the coastal zone of Semarang city, Indonesia

Abstract: Sea level rise (SLR) as a result of global warming has an impact on the increasing inundation on the coastal area. Nowadays, Semarang coastal area in Indonesia is already subject to coastal hazard due to tidal inundation and land subsidence. The impact of the inundation is predicted to be even more severe with the scenario of sea level rise. This paper concentrates on the risk assessment to the population, land use, and monetary losses as a result of coastal inundation under enhanced sea level rise. This paper uses the scenario of the depth of inundation to generate coastal inundation model using GIS-Technology. Anticipatory issues including methodology development for hazard assessment would be necessary for Semarang coastal area, and therefore, geo-information technology can be considered as a useful tool to rapidly assess the impact of the coastal hazard and evaluate the economic losses.

Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth.

Abstract: Curcumin has been reported to exhibit anti-tumorigenic activity; however, since its precise actions remain unclear, its effects are considered to be deceptive. In the present study, we confirmed the anti-tumorigenic effects of curcumin on CML-derived leukemic cells in a xenograft model and in vitro culture system. In vitro pull-down and mass analyses revealed a series of enzymes (carbonyl reductase, glutathione-S-transferase, glyoxalase, etc.) that function in a reactive oxygen species (ROS) metabolic pathway as curcumin-binding targets, the expression of which was up-regulated in human leukemia. Curcumin increased ROS levels over the threshold in leukemic cells, and the antioxidant, glutathione (GSH) and overexpression of curcumin-binding enzymes partially mitigated the up-regulation of ROS and growth inhibition caused by curcumin. These results show that curcumin specifically inhibits tumor growth by increasing ROS levels over the threshold through the miscellaneous inhibition of ROS metabolic enzymes. Curcumin has potential in therapy to regulate ROS levels in tumor cells, thereby controlling tumor growth.