Georgia College & State University

About: Georgia College & State University is a education organization based out in Milledgeville, Georgia, United States. It is known for research contribution in the topics: Population & Context (language use). The organization has 950 authors who have published 1591 publications receiving 37027 citations.

Body composition and bone mineral density in breast cancer survivors and non‐cancer controls: A 12‐ to 15‐month follow‐up

Abstract: While prognosis for breast cancer in women has improved, adverse side effects of treatments may negatively affect body composition and bone mineral density (BMD). This study assessed body composition and BMD changes in breast cancer survivors (BCS) (n = 10, 57.9 ± 5.7 years) and age-matched women (non-cancer, n = 10, 56.5 ± 4.3 years) over a 12- to 15-month period via dual-energy X-ray absorptiometry. No differences were observed between groups at baseline except forearm BMD values were lower in BCS (BCS: 0.462 ± 0.070 g/cm2 ; Control: 0.539 ± 0.052 g/cm2 , p = .012). Body fat increased in both groups compared to baseline (BCS: 38.3-39.6 kg, p = .013; Control: 38.2-39.5 kg, p = .023) at the follow-up. Significant decreases in BMD at the lumbar spine, femoral neck, total femur and ulna were observed in both groups. Breast cancer survivors had a greater decrease in left femoral neck BMD. While BCS demonstrated lower baseline forearm BMD values and a greater decrease in left femoral neck BMD, both groups showed an increase in body fat and decrease in forearm BMD. These findings support the implementation of interventions to improve body composition and BMD in both BCS and women without cancer.

Fossil Dennstaedtiaceae and Hymenophyllaceae from the Early Eocene of the Pacific Northwest

Abstract: Premise of research. Newly recognized compression fossils of fertile leptosporangiate ferns assignable to Dennstaedtia Bernh. (Dennstaedtiaceae) and Hymenophyllum Sm. (Hymenophyllaceae) are describ...

Pharmacokinetics of Metronidazole Administered as a Single Oral Bolus to Red Rat Snakes, Elaphe guttata

Abstract: The pharmacokinetics of metronidazole was evaluated in 16 red rat snakes, Elaphe guttata, after a single oral dose of 50 mg/kg (n=8) or 150 mg/kg (n=8). Blood samples were collected at predetermined intervals over a 48 hr period. Plasma concentrations of metronidazole were measured using high performance liquid chromatography (HPLC). Metronidazole dosed at 50 mg/kg was eliminated with a half-life of 11.1 hr. The apparent volume of distribution (steady state) was 0.053 L/kg, the apparent oral clearance was 3.04 ml/hr, and the mean residence time was 18.5 hr. The plasma concentration of metronidazole exceeded the recommended minimum inhibitory concentration (MIC) in both treatment groups at all time points for at least 48 hr. Based on this study it can be concluded that oral administration of 50 mg/kg of metronidazole to red rat snakes every 48 hr would maintain more than adequate plasma concentrations against susceptible anaerobic bacteria and protozoa.