Analysis of the gut microbiota in the old order Amish and its relation to the metabolic syndrome.
Margaret L. Zupancic,Brandi L. Cantarel,Zhenqiu Liu,Elliott F. Drabek,Kathleen A. Ryan,Shana Cirimotich,Cheron Jones,Rob Knight,William A. Walters,Dan Knights,Emmanuel F. Mongodin,Richard B. Horenstein,Braxton D. Mitchell,Nanette I. Steinle,Nanette I. Steinle,Soren Snitker,Alan R. Shuldiner,Alan R. Shuldiner,Claire M. Fraser +18 more
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TLDR
Network analysis identified twenty-two bacterial species and four OTUs that were either positively or inversely correlated with metabolic syndrome traits, suggesting that certain members of the gut microbiota may play a role in these metabolic derangements.Abstract:
Obesity has been linked to the human gut microbiota; however, the contribution of gut bacterial species to the obese phenotype remains controversial because of conflicting results from studies in different populations. To explore the possible dysbiosis of gut microbiota in obesity and its metabolic complications, we studied men and women over a range of body mass indices from the Old Order Amish sect, a culturally homogeneous Caucasian population of Central European ancestry. We characterized the gut microbiota in 310 subjects by deep pyrosequencing of bar-coded PCR amplicons from the V1–V3 region of the 16S rRNA gene. Three communities of interacting bacteria were identified in the gut microbiota, analogous to previously identified gut enterotypes. Neither BMI nor any metabolic syndrome trait was associated with a particular gut community. Network analysis identified twenty-two bacterial species and four OTUs that were either positively or inversely correlated with metabolic syndrome traits, suggesting that certain members of the gut microbiota may play a role in these metabolic derangements.read more
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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Vanessa K. Ridaura,Jeremiah J. Faith,Federico E. Rey,Jiye Cheng,Alexis E. Duncan,Andrew L. Kau,Nicholas W. Griffin,Vincent Lombard,Bernard Henrissat,Bernard Henrissat,James R. Bain,Michael J. Muehlbauer,Olga Ilkayeva,Clay F. Semenkovich,Katsuhiko Funai,David K. Hayashi,Barbara J. Lyle,Margaret C. Martini,Luke K. Ursell,Jose C. Clemente,Will Van Treuren,William A. Walters,Rob Knight,Rob Knight,Christopher B. Newgard,Andrew C. Heath,Jeffrey I. Gordon +26 more
TL;DR: The results reveal that transmissible and modifiable interactions between diet and microbiota influence host biology and that adiposity is transmissible from human to mouse and that it was associated with changes in serum levels of branched-chain amino acids.
Journal ArticleDOI
The gut microbiota and host health: a new clinical frontier
Julian R. Marchesi,David H. Adams,Francesca Fava,Gerben D. A. Hermes,Gideon M. Hirschfield,Georgina L. Hold,Mohammed Nabil Quraishi,James Kinross,Hauke Smidt,Kieran Tuohy,Linda V. Thomas,Erwin G. Zoetendal,Ailsa Hart +12 more
TL;DR: The potential of manipulating the gut microbiota in these disorders is assessed, with an examination of the latest and most relevant evidence relating to antibiotics, probiotics, prebiotics, polyphenols and faecal microbiota transplantation.
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The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?
Fabien Magne,Martin Gotteland,Lea Gauthier,Alejandra Zazueta,Susana A. Pesoa,Paola Navarrete,Ramadass Balamurugan +6 more
TL;DR: It is currently difficult to associate the Firmicutes/Bacteroidetes ratio with a determined health status and more specifically to consider it as a hallmark of obesity.
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The Integrative Human Microbiome Project
Lita M. Proctor,Heather Huot Creasy,Jennifer M. Fettweis,Jason Lloyd-Price,Anup Mahurkar,Wenyu Zhou,Gregory A. Buck,Michael Snyder,Jerome F. Strauss,George M. Weinstock,Owen White,Curtis Huttenhower +11 more
TL;DR: Over ten years, the Human Microbiome Project has provided resources for studying the microbiome and its relationship to disease; this Perspective summarizes the key achievements and findings of the project and its relation to the broader field.
Journal ArticleDOI
Meta-analyses of human gut microbes associated with obesity and IBD.
TL;DR: It is found that IBD has a consistent signature across studies and allows high classification accuracy of IBD from non‐IBD subjects, but that signatures of obesity are not consistent between studies even when the data are analyzed with consistent methods.
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