Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation.
Tiansheng Li,Tiansheng Li,Chao Mao,Chao Mao,Xiang Wang,Ying Shi,Ying Shi,Yongguang Tao,Yongguang Tao +8 more
TLDR
A more systematic review from epigenetic perspective is made, helping others better understand hypoxia or HIF pathway, and providing more established and potential therapeutic strategies in tumors to facilitate epigenetic studies of tumors.Abstract:
Hypoxia is the major influence factor in physiological and pathological courses which are mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions within solid tumors. Under normoxia, HIF signaling pathway is inhibited due to HIF-α subunits degradation. However, in hypoxic conditions, HIF-α is activated and stabilized, and HIF target genes are successively activated, resulting in a series of tumour-specific activities. The activation of HIFs, including HIF-1α, HIF-2α and HIF-3α, subsequently induce downstream target genes which leads to series of responses, the resulting abnormal processes or metabolites in turn affect HIFs stability. Given its functions in tumors progression, HIFs have been regarded as therapeutic targets for improved treatment efficacy. Epigenetics refers to alterations in gene expression that are stable between cell divisions, and sometimes between generations, but do not involve changes in the underlying DNA sequence of the organism. And with the development of research, epigenetic regulation has been found to play an important role in the development of tumors, which providing accumulating basic or clinical evidences for tumor treatments. Here, given how little has been reported about the overall association between hypoxic tumors and epigenetics, we made a more systematic review from epigenetic perspective in hope of helping others better understand hypoxia or HIF pathway, and providing more established and potential therapeutic strategies in tumors to facilitate epigenetic studies of tumors.read more
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Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition
吳明祖(Min-Zu Wu),蔡雅萍(Ya-Ping Tsai),楊慕華(Muh-Hwa Yang),黃奇宏(Chi-Hung Huang),張學逸(Shyue-Yih Chang),張正琪(Cheng-Chi Chang),鄧述諄(Shu-Chun Teng),吳國瑞(Kou-Juey Wu) +7 more
Journal ArticleDOI
Emerging mechanisms and targeted therapy of ferroptosis in cancer
TL;DR: Ferroptosis is an iron and lipid reactive oxygen species (ROS)-dependent form of programmed cell death that is distinct from other forms of regulatory cell death at morphological, biological, and genetic levels as discussed by the authors.
Journal ArticleDOI
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Zhen Luo,Mingfu Tian,George Q. Yang,Qiaoru Tan,Yubing Chen,Geng Li,Qiwei Zhang,Yongkui Li,Pin Wan,Jianguo Wu +9 more
TL;DR: The mechanisms of hypoxia signaling activation, the control of Hif signaling, and the function of HIF signaling in human health and diseases are reviewed to provide novel strategies for the design and development of therapeutic drugs.
Journal ArticleDOI
YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis
TL;DR: In this paper , the role of the YTHDF1-PKM2 signal axis in the occurrence and development of breast cancer was identified, which can be used as a potential target for breast cancer treatment.
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Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node.
Yang Fang,Xifeng Wang,Danying Yang,Yimei Lu,Gen Wei,Wen Yu,Xing Liu,Qingcui Zheng,Jun Ying,Fuzhou Hua +9 more
TL;DR: The Silent Information Regulator-1 (SIRT1) is a multipotent molecule that participates in the regulation of important biological processes in cells, including cellular metabolism, cell senescence, and inflammation.
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TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.
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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands
TL;DR: The use of MSP is demonstrated to identify promoter region hypermethylation changes associated with transcriptional inactivation in four important tumor suppressor genes (p16, p15, E-cadherin and von Hippel-Lindau) in human cancer.