International network of cancer genome projects

doi:10.1038/NATURE08987

Open AccessJournal ArticleDOI

International network of cancer genome projects

- Vol. 464, Iss: 7291, pp 993-998

TLDR

Systematic studies of more than 25,000 cancer genomes will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

Abstract:

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

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References

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Open Access

More filters

Journal ArticleDOI

The hallmarks of cancer.

Douglas Hanahan, +1 more

- 07 Jan 2000 -

Cell

TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.

...read moreread less

Journal ArticleDOI

Mapping and quantifying mammalian transcriptomes by RNA-Seq.

Ali Mortazavi, +4 more

- 29 Jun 2008 -

Nature Methods

TL;DR: Although >90% of uniquely mapped reads fell within known exons, the remaining data suggest new and revised gene models, including changed or additional promoters, exons and 3′ untranscribed regions, as well as new candidate microRNA precursors.

...read moreread less

Journal ArticleDOI

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

Dennis J. Slamon, +11 more

- 15 Mar 2001 -

The New England Journal of Medicine

TL;DR: The addition of trastuzumab to chemotherapy was associated with a longer time to disease progression, a higher rate of objective response, a longer duration of response, and a lower rate of death at 1 year.

...read moreread less

Journal ArticleDOI

Mutations of the BRAF gene in human cancer

Helen Davies, +51 more

- 27 Jun 2002 -

Nature

TL;DR: BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%.

...read moreread less

Journal ArticleDOI

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Roger E. McLendon, +233 more

- 23 Oct 2008 -

Nature

TL;DR: The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.

...read moreread less