Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
Reads0
Chats0
TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
More filters
Journal ArticleDOI
MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases.
TL;DR: The potential use of miRNAs as clinically diagnostic biomarkers of various cancers and other diseases are discussed as well as the approaches used to detect these molecules in serum and plasma.
Journal ArticleDOI
MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses.
Shigeru Miyaki,Tomoyuki Nakasa,Shuhei Otsuki,Shawn P. Grogan,Reiji Higashiyama,Atsushi Inoue,Yoshio Kato,Tempei Sato,Martin Lotz,Hiroshi Asahara +9 more
TL;DR: This study shows that miR-140 has a chondrocyte differentiation-related expression pattern that may contribute to the abnormal gene expression pattern characteristic of OA.
Journal ArticleDOI
Loss of mir-146a function in hormone-refractory prostate cancer.
TL;DR: Down-regulated mir-146a may function as a tumor-suppressor gene in modulating HA/ROCK1-mediated tumorigenecity in androgen-dependent prostate cancer.
Journal ArticleDOI
A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer.
TL;DR: The observations from this pilot study suggest that the altered levels of circulating miRNAs might have great potential to serve as novel, noninvasive biomarkers for early detection of breast cancer.
Journal ArticleDOI
MicroRNA Expression Profiles of Esophageal Cancer
Andrew Feber,Liqiang Xi,James D. Luketich,Arjun Pennathur,Rodney J. Landreneau,Maoxin Wu,Scott J. Swanson,Tony E. Godfrey,Virginia R. Litle +8 more
TL;DR: Examination of microRNA expression in Barrett esophagus and esophageal cancer to identify potential markers for disease progression revealed microRNAs that may be markers of tumor progression that can discriminate normal tissue from tumor.
References
More filters
Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
Related Papers (5)
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more