Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
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TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
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Journal ArticleDOI
Circulating microRNAs in breast cancer and healthy subjects.
TL;DR: In this article, the authors measured miRNA in the serum of samples with and without the addition of miRNA prior to analysis, and they were able to detect the miRNAs from all the serum samples to which the miRNA had been added.
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MicroRNAs in colorectal cancer: translation of molecular biology into clinical application
TL;DR: The knowledge regarding miRNAs' functioning in CRC is summarized while emphasizing their significance in pathogenetic signaling pathways and their potential to serve as disease biomarkers and novel therapeutic targets.
Journal ArticleDOI
Low-Level Expression of MicroRNAs let-7d and miR-205 Are Prognostic Markers of Head and Neck Squamous Cell Carcinoma
Geoffrey Childs,Melissa Fazzari,Gloria Kung,Nicole Kawachi,Margaret Brandwein-Gensler,Michael Steven McLemore,Quan Chen,Robert D. Burk,Richard V. Smith,Michael B. Prystowsky,Thomas J. Belbin,Nicolas F. Schlecht +11 more
TL;DR: It is shown that miRNA expression levels can be used as prognostic markers of head and neck cancer and low levels of hsa-miR205 are significantly associated with loco-regional recurrence independent of disease severity at diagnosis and treatment.
Journal ArticleDOI
Over- and under-expressed microRNAs in human colorectal cancer
Kazuo Motoyama,Hiroshi Inoue,Yasushi Takatsuno,Yasushi Takatsuno,Fumiaki Tanaka,Koshi Mimori,Hiroyuki Uetake,Kenichi Sugihara,Masaki Mori +8 more
TL;DR: This study identified miRNAs that were overexpressed or under-expressed in colorectal cancers and which may be correlated with coloreCTal carcinogenesis.
Journal ArticleDOI
Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available
TL;DR: Novel technological approaches to estimate the expression levels of microRNAs (miRNAs) using real-time quantitative PCR (qPCR) are introduced and existing qPCR profiling methodologies are compared.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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