Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
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Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma
Guo Yong,Zhaoli Chen,Liang Zhang,Fang Zhou,Su-sheng Shi,Xiaoli Feng,Baozhong Li,Xin Meng,Xi Ma,Mingyong Luo,Kang Shao,Ning Li,Bin Qiu,Keith Mitchelson,Jing Cheng,Jie He +15 more
TL;DR: The results indicate that microRNA expression profiles are important diagnostic and prognostic markers of esophageal cancer, which might be analyzed simply using economical approaches such as reverse transcription-PCR.
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A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells
Sonia A. Melo,Catia Moutinho,Santiago Ropero,George A. Calin,Simona Rossi,Riccardo Spizzo,Agustín F. Fernández,Veronica Davalos,Alberto Villanueva,Guillermo Montoya,Hiroyuki Yamamoto,Simó Schwartz,Manel Esteller +12 more
TL;DR: The restoration of XPO5 functions reverses the impaired export of pre-miRNAs and has tumor-suppressor features.
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Lost in translation: an assessment and perspective for computational microRNA target identification.
Panagiotis Alexiou,Manolis Maragkakis,Giorgos L. Papadopoulos,Martin Reczko,Artemis G. Hatzigeorgiou +4 more
TL;DR: The basic idea behind the experimental identification of miRNA targets is introduced and some of the most widely used computational miRNA target identification programs are presented, including an assessment of the prediction quality of these programs and their combinations.
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miR-210 Links Hypoxia with Cell Cycle Regulation and Is Deleted in Human Epithelial Ovarian Cancer
Antonis Giannakakis,Raphael Sandaltzopoulos,Joel Greshock,Shun Liang,Jia Huang,Kosei Hasegawa,Chunsheng Li,Ann O'Brien-Jenkins,Dionyssios Katsaros,Barbara L. Weber,Celeste Simon,George Coukos,Lin Zhang +12 more
TL;DR: The results indicate that miR-210 plays a crucial role in tumor onset as a key regulator of the hypoxia response and provide evidence for a link between hypoxic conditions and the regulation of cell cycle.
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Highly Sensitive and Selective Strategy for MicroRNA Detection Based on WS2 Nanosheet Mediated Fluorescence Quenching and Duplex-Specific Nuclease Signal Amplification
TL;DR: WS2 nanosheet can exhibit differential affinity toward short oligonucleotide fragment versus ssDNA probe and act as an efficient quencher for adsorbed fluorescent probes and indicates that this simple and cost-effective strategy holds great potential application in biomedical research and clinical diagnostics.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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