Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
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TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
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Identification of ten serum microRNAs from a genome‐wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis
Xi Chen,Zhibin Hu,Wenjing Wang,Yi Ba,Lijia Ma,Lijia Ma,Chunni Zhang,Cheng Wang,Zhiji Ren,Yang Zhao,Sijia Wu,Rui Zhuang,Yixin Zhang,Heng Hu,Cha-Zhen Liu,Lin Xu,Jun Wang,Jun Wang,Hongbing Shen,Junfeng Zhang,Ke Zen,Chen-Yu Zhang +21 more
TL;DR: The profiling of 10‐serum miRNAs provides a novel noninvasive biomarker for NSCLC diagnosis and was supported by a retrospective analysis in which the 10‐Serum miRNA profile could accurately classify serum samples collected up to 33 months ahead of the clinical NSCLc diagnosis.
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Liver‐enriched transcription factors regulate MicroRNA‐122 that targets CUTL1 during liver development
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A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer.
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miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.
TL;DR: This study reveals a tumor suppressor function of miR-449a/b through regulating Rb/E2F1 activity, and suggests that escape from this regulation through an aberrant epigenetic event contributes to E 2F1 deregulation and unrestricted proliferation in human cancer.
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MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a.
Yu Zhang,Yu Zhang,Tengfei Chao,Tengfei Chao,Ran Li,Ran Li,Wei Liu,Wei Liu,Yang Chen,Yang Chen,Xingqi Yan,Xingqi Yan,Yanhua Gong,Bin Yin,Boqing Qiang,Jizhong Zhao,Jiangang Yuan,Xiaozhong Peng +17 more
TL;DR: It is demonstrated that brain-enriched miR-128 is down-regulated in glioma tissues and cell lines when compared to normal brain tissues and can inhibit proliferation ofglioma cells through one of its targets, E2F3a.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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