Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
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TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
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Systematic Analysis of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer Cells.
Päivi Östling,Suvi-Katri Leivonen,Anna Aakula,Anna Aakula,Pekka Kohonen,Rami Mäkelä,Zandra Hagman,Anders Edsjö,Sara Kangaspeska,Henrik Edgren,Daniel Nicorici,Anders Bjartell,Yvonne Ceder,Merja Perälä,Olli Kallioniemi,Olli Kallioniemi,Olli Kallioniemi +16 more
TL;DR: It is established that miRNAs interacting with the long 3'UTR of the AR gene are important regulators of AR protein levels, with implications for developing new therapeutic strategies to inhibit AR function and androgen-dependent cell growth.
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Multiplexed detection methods for profiling microRNA expression in biological samples
TL;DR: Some of the latest methods for high-throughput miRNA profiling and the unique technological challenges that must be surmounted in this endeavor are discussed.
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mRNA and microRNA quality control for RT-qPCR analysis
TL;DR: Results showed that this analysis method is strongly influenced by total RNA integrity, which is known to affect the performance of RT-qPCR as well as the quantitative results in mRNA expression profiling.
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Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines
Shingo Mitomo,Chihaya Maesawa,Satoshi Ogasawara,Takeshi Iwaya,Masahiko Shibazaki,Akiko Yashima-Abo,Koji Kotani,Hiroki Oikawa,Eiich Sakurai,Naoko Izutsu,Kuniyuki Kato,Hideaki Komatsu,K. Ikeda,Go Wakabayashi,Tomoyuki Masuda +14 more
TL;DR: The expression of multiple miRNA and their functional effects on target genes in human thyroid carcinoma cell lines are examined to suggest that loss of miR‐138 expression may partially contribute to the gain of hTERT protein expression in ATC, and that further multiple miRNAs targeting h TERT mRNA might be involved in the development of thyroid carcinomas.
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Molecular Biology of Lung Cancer: Clinical Implications
Kwun M. Fong,John D. Minna +1 more
TL;DR: Current information on the key molecular steps in lung cancer pathogenesis, their timing, and clinical implications are reviewed.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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