Open AccessJournal Article
Oncomirs : microRNAs with a role in cancer
TLDR
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.Abstract:
I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.read more
Citations
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MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity.
TL;DR: The emerging roles of microRNAs in the establishment and maintenance of ESC identity are discussed and the current understanding of the mechanisms controlling microRNA expression and function in ESCs is summarized.
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Bead‐based microarray analysis of microRNA expression in hepatocellular carcinoma: miR‐338 is downregulated
Xiao-Hui Huang,Qian Wang,Jing-Song Chen,Xin-hui Fu,Xi-Lin Chen,Lian-zhou Chen,Wen Li,Jiong Bi,Long-juan Zhang,Qian Fu,Wen-Tao Zeng,Liang-qi Cao,Hao-xiang Tan,Qiao Su +13 more
TL;DR: The relevance of abnormally expressed miRNA to tumor biology has not been well understood in hepatocellular carcinoma (HCC) and this work aims to address this issue.
Journal ArticleDOI
MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets.
Nancy Garbacki,Emmanuel Di Valentin,Vân Anh Huynh-Thu,Pierre Geurts,Alexandre Irrthum,Céline Crahay,Thierry Arnould,Christophe Deroanne,Jacques Piette,Didier Cataldo,Alain Colige +10 more
TL;DR: It is highlighted that specific miRNAs are likely to be involved in asthma disease and could represent a valuable resource both for biological makers identification and for unveiling mechanisms underlying the pathogenesis of asthma.
Journal ArticleDOI
Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia
Vinod Kumar,Rocco Palermo,Claudio Talora,Antonio Francesco Campese,Saula Checquolo,Diana Bellavia,Luca Tottone,G Testa,Evelina Miele,Stefano Indraccolo,Alberto Amadori,Elisabetta Ferretti,Alberto Gulino,Alberto Gulino,Alessandra Vacca,Isabella Screpanti,Isabella Screpanti +16 more
TL;DR: Notch signaling deregulation is linked to the onset of several tumors including T-cell acute lymphoblastic leukemia (T-ALL) and miRNAs regulated by Notch pathway are identified, including miR-223, whose putative promoter analysis revealed a conserved RBPjk binding site, which was nested to an NF-kB consensus.
Book ChapterDOI
Endonucleolytic initiation of mRNA decay in Escherichia coli.
TL;DR: Current models for mRNA degradation in E. coli are discussed and current thinking on the structure and function of RNase E is presented based on recent crystal structures of its catalytic core.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
Prediction of Mammalian MicroRNA Targets
TL;DR: The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions.
Journal ArticleDOI
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee,Chiyoung Ahn,Jinju Han,Hyounjeong Choi,Jaekwang Kim,Jeongbin Yim,Junho Lee,Patrick Provost,Olof Rådmark,Sun-Young Kim,V. Narry Kim +10 more
TL;DR: The two RNase III proteins, Drosha and Dicer, may collaborate in the stepwise processing of miRNAs, and have key roles in miRNA-mediated gene regulation in processes such as development and differentiation.
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