SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.About:
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.read more
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A Single-Cell Atlas of the Human Healthy Airways.
Marie Deprez,Laure-Emmanuelle Zaragosi,Marin Truchi,Christophe Bécavin,Sandra Ruiz García,Marie-Jeanne Arguel,Magali Plaisant,Virginie Magnone,Kevin Lebrigand,Sophie Abelanet,Frédéric Brau,Agnès Paquet,Dana Pe'er,Charles-Hugo Marquette,Sylvie Leroy,Sylvie Leroy,Pascal Barbry +16 more
TL;DR: The precise description of the continuum existing from the nasal epithelium to successive divisions of the airways and the stable gene expression profile of these regions better defines conditions under which relevant tracheobronchial proxies of human respiratory diseases can be developed.
Journal ArticleDOI
COVID-19-associated coagulopathy: An exploration of mechanisms.
Meaghan Colling,Yogendra Kanthi +1 more
TL;DR: It is hypothesized that an imbalance between coagulation and inflammation may result in a hypercoagulable state in patients with COVID-19 and that hemostatic imbalances may contribute to the pathophysiology of SARS-CoV-2 infection.
Journal ArticleDOI
Microvascular dysfunction in COVID-19: the MYSTIC study.
Alexandros Rovas,Irina Osiaevi,Konrad Buscher,Jan Sackarnd,Phil-Robin Tepasse,Manfred Fobker,Joachim Kuhn,Stephan Braune,Ulrich Göbel,Gerold Thölking,Andreas Gröschel,Hermann Pavenstädt,Hans Vink,Philipp Kümpers +13 more
TL;DR: The authors' data clearly show severe alterations of the microcirculation and the endothelial glycocalyx in patients with CO VID-19, and future therapeutic approaches should consider the importance of systemic vascular involvement in COVID-19.
Posted ContentDOI
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Miao-Miao Zhao,Wei-Li Yang,Fang-Yuan Yang,Li Zhang,Weijin Huang,Wei Hou,Changfa Fan,Rong-Hua Jin,Yingmei Feng,Youchun Wang,Jin-Kui Yang +10 more
TL;DR: The crucial role of cathepsin L (CTSL) in patients with COVID-19 is reported and it is found that CTSL functionally cleaved the SARS-CoV-2 spike protein and enhanced virus entry, as evidenced by C TSL overexpression and knockdown in vitro and application of CTSS inhibitor drugs in vivo.
Journal ArticleDOI
SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions.
Mohammed Uddin,Mohammed Uddin,Farah Mustafa,Tahir A. Rizvi,Tom Loney,Hanan Al Suwaidi,Ahmed H. Al-Marzouqi,Afaf Kamal Eldin,Nabeel Alsabeeha,Thomas E. Adrian,Cesare Stefanini,Norbert Nowotny,Norbert Nowotny,Alawi A. Alsheikh-Ali,Abiola Senok +14 more
TL;DR: This review provides a comprehensive overview of COVID-19 epidemiology, genomic etiology, findings from recent transcriptomic map analysis, viral-human protein interactions, molecular diagnostics, and the current status of vaccine and novel therapeutic intervention development.
References
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.
Jasper Fuk-Woo Chan,Shuofeng Yuan,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Hin Chu,Jin Yang,Fanfan Xing,Jieling Liu,Cyril C. Y. Yip,Rosana W.S. Poon,Hoi Wah Tsoi,Simon Kam Fai Lo,Kwok-Hung Chan,Vincent Kwok-Man Poon,Wan Mui Chan,Jonathan Daniel Ip,Jian Piao Cai,Vincent C.C. Cheng,Honglin Chen,Honglin Chen,Christopher K.M. Hui,Kwok-Yung Yuen +22 more
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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