SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.About:
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.read more
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ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.
Cheng Wang,Mingzi Zhang,Gustavo Garcia,E Tian,Qi Cui,Xianwei Chen,Guihua Sun,Jinhui Wang,Vaithilingaraja Arumugaswami,Yanhong Shi +9 more
TL;DR: ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with increased risk for severe COVID-19 as discussed by the authors, but it is unclear whether ApoE4 alters COVID19 susceptibility or severity, and the role of direct viral infection in brain cells remains obscure.
Journal ArticleDOI
Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions.
TL;DR: Emerging knowledge on the basic biological pathways that underlie differences in immune responses between women and men needs to be incorporated into research efforts on SARS-CoV-2 pathogenesis and pathology to identify targets for therapeutic interventions aimed at enhancing antiviral immune function and lung airway resilience while reducing pathogenic inflammation in COVID-19.
Journal ArticleDOI
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection.
Min Zheng,Evan P. Williams,R. K. Subbarao Malireddi,Rajendra Karki,Balaji Banoth,Amanda R. Burton,Richard J. Webby,Rudragouda Channappanavar,Colleen B. Jonsson,Thirumala-Devi Kanneganti +9 more
TL;DR: The findings show that inflammatory cell death, PANoptosis, is induced by coronavirus infection and that impaired NLRP3 inflammasome function or pyroptosis can lead to negative consequences for the host.
Journal ArticleDOI
Brief Review on COVID-19: The 2020 Pandemic Caused by SARS-CoV-2
TL;DR: A brief review of viral origin, identification, symptoms, transmission, diagnosis, and potential treatment strategies for the newly identified SARS-CoV-2 strain is provided.
Journal ArticleDOI
COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside
David Sulzer,Angelo Antonini,Valentina Leta,Valentina Leta,Anna S. Nordvig,Richard J. Smeyne,James E. Goldman,Osama Al-Dalahmah,Luigi Zecca,Alessandro Sette,Alessandro Sette,Luigi Bubacco,Olimpia Meucci,Elena Moro,Elena Moro,Ashley S. Harms,Yaqian Xu,Stanley Fahn,K. Ray Chaudhuri,K. Ray Chaudhuri +19 more
TL;DR: While a role for the virus in causing or exacerbating Parkinson’s disease appears unlikely at this time, aggravation of specific motor and non-motor symptoms has been reported, and it will be important to monitor subjects after recovery, particularly for those with persisting hyposmia.
References
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TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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