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Open AccessJournal ArticleDOI

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, +13 more
- 16 Apr 2020 - 
- Vol. 181, Iss: 2, pp 271
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
About: 
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.

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Pharmacological therapeutics targeting RNA-dependent RNA polymerase, proteinase and spike protein: From mechanistic studies to clinical trials for COVID-19

Jiansheng Huang, +3 more
- 15 Apr 2020 - 
TL;DR: Differing the structural-functional relationships of the S protein of SARS-CoV-2 will provide new insights into inhibition of interactions between S protein and angiotensin-converting enzyme 2 (ACE2) and enable us to develop novel therapeutic approaches for novel coronavirus Sars-Cov-2.
Journal ArticleDOI

Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities.

Rolando Cannalire, +4 more
- 13 Nov 2020 - 
TL;DR: An exhaustive comparative analysis of SARS-CoV-2 proteases and RdRp with respect to other coronavirus homologues is provided, and the most promising inhibitors of these proteins reported so far are highlighted, including the possible strategies for their further development.
Journal ArticleDOI

SARS-COV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.

Agustin Conde-Agudelo, +2 more
- 21 Jul 2021 - 
TL;DR: In this article, the authors examined the relationship between SARS-CoV-2 infection during pregnancy and the risk for preeclampsia and found that SARS infection was associated with higher odds of preeclampia.
Journal ArticleDOI

Review of indoor aerosol generation, transport, and control in the context of COVID-19.

Michael A. Kohanski, +2 more
- 24 Jul 2020 - 
TL;DR: Understanding principles of infectious transmission, aerosol and droplet generation, as well as concepts of indoor airflow, will assist in the integration of new data on SARS‐CoV‐2 transmission and activities that can generate aerosol to best inform on the need for escalation or de‐escalation from current societal and institutional guidelines for protection during aerosol‐generating procedures.
Journal ArticleDOI

Quantitative measurement of anti-SARS-CoV-2 antibodies: Analytical and clinical evaluation.

Victoria Higgins, +3 more
- 19 Mar 2021 - 
TL;DR: In this article, the Elecsys anti-SARS-CoV-2 S assay was used to diagnose severe acute respiratory syndrome coronavirus 2 (SARS CoV2) in COVID-19 patients.
References
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Journal ArticleDOI

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.

Sudhir Kumar, +5 more
- 01 Jun 2018 - 
TL;DR: The Molecular Evolutionary Genetics Analysis (Mega) software implements many analytical methods and tools for phylogenomics and phylomedicine and has additionally been upgraded to use multiple computing cores for many molecular evolutionary analyses.
Journal ArticleDOI

A Novel Coronavirus from Patients with Pneumonia in China, 2019.

Na Zhu, +18 more
- 24 Jan 2020 - 
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, +28 more
- 03 Feb 2020 - 
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.

Jasper Fuk-Woo Chan, +22 more
- 15 Feb 2020 - 
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.

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