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Open AccessJournal ArticleDOI

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, +13 more
- 16 Apr 2020 - 
- Vol. 181, Iss: 2, pp 271
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
About: 
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.

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The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET.

Chuang Liu, +22 more
- 03 Nov 2020 - 
TL;DR: This work genetically and structurally characterized β-propiolactone-inactivated viruses from a propagated and purified clinical strain of SARS-CoV-2 and observed that the virus particles are roughly spherical or moderately pleiomorphic, thus resembling a postfusion state.
Journal ArticleDOI

Comprehensive characterization of N- and O- glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2.

Asif Shajahan, +5 more
- 03 May 2021 - 
TL;DR: Glycomic and glycoproteomic analysis of hACE2 expressed in HEK293 cells is described and elucidation of the site-specific glycosylation and its terminal orientations on the h ACE2 receptor can aid in understanding the intriguing virus-receptor interactions and assist in the development of novel therapeutics to prevent viral entry.
Posted ContentDOI

SARS-CoV-2 immune evasion by variant B.1.427/B.1.429

Matthew McCallum, +30 more
- 01 Apr 2021 - 
TL;DR: In this article, neutralizing antibody responses to SARS-CoV-2 infection or to the prototypic Wuhan-1 isolate-based vaccines will be impacted by the three B.1.20C (B.1,1.1.,1.429) mutations: S13I, W152C and L452R, which reduced neutralizing activity of 14 out of 35 RBD-specific monoclonal antibodies.
Journal ArticleDOI

SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45 - Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome.

Mariusz Z. Ratajczak, +7 more
- 01 Feb 2021 - 
TL;DR: There is a possibility that human VSELs residing in adult tissues could be damaged by SARS-CoV-2, with remote effects on tissue/organ regeneration, and the data indicates that Ang 1–7 may have a protective effect.
Journal ArticleDOI

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

Farhana Rumzum Bhuiyan, +3 more
- 07 Aug 2020 - 
TL;DR: It is revealed that the proposed plant metabolites can serve as potential anti- SARS-CoV-2 lead molecules for further optimization and drug development processes to combat COVID-19 and future pandemics caused by viruses.
References
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Journal ArticleDOI

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.

Sudhir Kumar, +5 more
- 01 Jun 2018 - 
TL;DR: The Molecular Evolutionary Genetics Analysis (Mega) software implements many analytical methods and tools for phylogenomics and phylomedicine and has additionally been upgraded to use multiple computing cores for many molecular evolutionary analyses.
Journal ArticleDOI

A Novel Coronavirus from Patients with Pneumonia in China, 2019.

Na Zhu, +18 more
- 24 Jan 2020 - 
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, +28 more
- 03 Feb 2020 - 
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.

Jasper Fuk-Woo Chan, +22 more
- 15 Feb 2020 - 
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
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A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, +28 more
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.

Daniel Wrapp, +7 more
- 13 Mar 2020 - 

A Novel Coronavirus from Patients with Pneumonia in China, 2019.

Na Zhu, +18 more
- 24 Jan 2020 - 

Clinical Characteristics of Coronavirus Disease 2019 in China.

Wei-jie Guan, +36 more
- 28 Feb 2020 -