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Open AccessJournal ArticleDOI

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, +13 more
- 16 Apr 2020 - 
- Vol. 181, Iss: 2, pp 271
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
About: 
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.

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Silent hypoxia: A harbinger of clinical deterioration in patients with COVID-19.

R. Gentry Wilkerson, +3 more
- 22 May 2020 - 
TL;DR: A 72-year-old male with COVID-19 syndrome who presented to the emergency department with minimal symptoms but low peripheral oxygen saturation readings eventually died as a result of overwhelming multi-organ system failure, highlighting the utility of peripheral oxygen measurements in the evaluation of patients with SARS-CoV-2 infection.
Journal ArticleDOI

Comparison of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Binding to ACE2 Receptors from Human, Pets, Farm Animals, and Putative Intermediate Hosts.

Xiaofeng Zhai, +9 more
- 16 Jul 2020 - 
TL;DR: X-ray structures of human ACE2 bound to the receptor-binding domain (RBD) of the spike protein (S) from SARS-CoV-2 are used to predict its binding to ACE2 proteins from different animals, including pets, farm animals, and putative intermediate hosts of Sars-Cov-2, and it is found that ACE2 from species known to support SATS infection tolerate many amino acid changes, indicating that the species barrier might be low.
Journal ArticleDOI

Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity.

Yuanmei Zhu, +4 more
- 01 Jul 2020 - 
TL;DR: This study verified that SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) as a cell receptor and that its spike (S) protein mediates high membrane fusion activity, and designed an HR2 sequence-based lipopeptide fusion inhibitor, termed IPB02, which showed highly potent activities in inhibiting Sars-Cov-2 S protein-mediated cell-cell fusion and pseudovirus transduction.
Journal ArticleDOI

Dexamethasone for the Treatment of Coronavirus Disease (COVID-19): a Review.

Mukhtar Ahmed, +1 more
TL;DR: Low doses of corticosteroids (dexamethasone) could reduce the mortality in patients with severe COVID-19 disease; however, they had no effect on the mortality rate of those patients with a mild form of the condition.
Posted ContentDOI

The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity and decreases neutralization sensitivity to individual convalescent sera

Jie Hu, +11 more
- 20 Jun 2020 - 
TL;DR: Using pseudovirus-based assay, it is found that S-D614 and S-G614 protein pseudotyped viruses share a common receptor, human angiotensin-converting enzyme 2 (ACE2), which could be blocked by recombinant ACE2 with the fused Fc region of human IgG1.
References
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Journal ArticleDOI

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.

Sudhir Kumar, +5 more
- 01 Jun 2018 - 
TL;DR: The Molecular Evolutionary Genetics Analysis (Mega) software implements many analytical methods and tools for phylogenomics and phylomedicine and has additionally been upgraded to use multiple computing cores for many molecular evolutionary analyses.
Journal ArticleDOI

A Novel Coronavirus from Patients with Pneumonia in China, 2019.

Na Zhu, +18 more
- 24 Jan 2020 - 
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, +28 more
- 03 Feb 2020 - 
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.

Jasper Fuk-Woo Chan, +22 more
- 15 Feb 2020 - 
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.

Daniel Wrapp, +7 more
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A Novel Coronavirus from Patients with Pneumonia in China, 2019.

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Clinical Characteristics of Coronavirus Disease 2019 in China.

Wei-jie Guan, +36 more
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