SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.About:
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.read more
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SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
Si Zhang,Yangyang Liu,Xiaofang Wang,Li Yang,Haishan Li,Yuyan Wang,Mengduan Liu,Xiaoyan Zhao,Youhua Xie,Yan Yang,Shenghui Zhang,Zhichao Fan,Jianzeng Dong,Zhenghong Yuan,Zhongren Ding,Yi Zhang,Liang Hu +16 more
TL;DR: A novel function of SARS-CoV-2 on platelet activation via binding of Spike to ACE2 is uncovered, which may participate in thrombus formation and inflammatory responses in COVID-19 patients.
Journal ArticleDOI
Omicron Variant (B.1.1.529): Infectivity, Vaccine Breakthrough, and Antibody Resistance
TL;DR: An artificial intelligence model, which has been trained with tens of thousands of experimental data and extensively validated by experimental results on SARS-CoV-2, reveals that Omicron may be over 10 times more contagious than the original virus or about 2.8 times as infectious as the Delta variant.
Journal ArticleDOI
How COVID-19 induces cytokine storm with high mortality
Shintaro Hojyo,Mona Uchida,Kumiko Tanaka,Rie Hasebe,Yuki Tanaka,Masaaki Murakami,Toshio Hirano +6 more
TL;DR: It is hypothesize that IL-6-STAT3 signaling is a promising therapeutic target for the cytokine storm in COVID-19, because IL- 6 is a major STAT3 stimulator, particularly during inflammation.
Journal ArticleDOI
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
Kui K. Chan,Danielle Dorosky,Preeti Sharma,Shawn A. Abbasi,John M. Dye,David M. Kranz,Andrew S. Herbert,Erik Procko +7 more
TL;DR: A variant of ACE2 based on deep mutagenesis far outcompetes the natural receptor in binding the SARS-CoV-2 spike protein and gives ACE2 variants with affinities that rival those of monoclonal antibodies.
Journal ArticleDOI
Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532).
Monica Montopoli,Sara Zumerle,Roberto Vettor,Massimo Rugge,Manuel Zorzi,Carlo V. Catapano,Giuseppina M. Carbone,Andrea Cavalli,Francesco Pagano,Eugenio Ragazzi,Tommaso Prayer-Galetti,Andrea Alimonti +11 more
TL;DR: It is suggested that cancer patients have an increased risk of SARS-CoV-2 infections than non-cancer patients, however, prostate cancer patients receiving androgen-deprivation therapy (ADT) appear to be partially protected from Sars- CoV- 2 infections.
References
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TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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