SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.About:
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.read more
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Cytokine storm syndrome in coronavirus disease 2019: A narrative review.
TL;DR: The pathogenesis, clinical manifestation of CSS, and current understanding about the recognition and potential therapeutic options of CSS in COVID‐19 are summarized.
Journal ArticleDOI
COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies.
Vrishali S. Salian,Jessica A. Wright,Peter T. Vedell,Sanjana Nair,Chenxu Li,Mahathi Kandimalla,Xiaojia Tang,Eva M. Carmona Porquera,Krishna R. Kalari,Karunya K. Kandimalla +9 more
TL;DR: In this article, the authors provided an overview of COVID-19 etiology vis-a-vis other zoonotic diseases, particularly SARS and MERS, and summarized various approaches and technologies employed to develop vaccines against COVID19 and summarized the attempts to repurpose various classes of drugs and novel therapeutic approaches.
Journal ArticleDOI
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery.
Apoorva Mulay,Bindu Konda,Gustavo Garcia,Changfu Yao,Stephen Beil,Jaquelyn M. Villalba,Jaquelyn M. Villalba,Colin Koziol,Chandani Sen,Arunima Purkayastha,Jay K. Kolls,Derek Pociask,Patrizia Pessina,Patrizia Pessina,Julio Sainz de Aja,Julio Sainz de Aja,Carolina Garcia-de-Alba,Carolina Garcia-de-Alba,Carla F. Kim,Carla F. Kim,Brigitte N. Gomperts,Vaithilingaraja Arumugaswami,Barry R. Stripp +22 more
TL;DR: Wang et al. as discussed by the authors developed primary human lung epithelial infection models to understand initial responses of proximal and distal lung epithelium to SARS-CoV-2 infection.
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SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.
Antoine Rebendenne,Ana Luiza Chaves Valadão,Marine Tauziet,Ghizlane Maarifi,Boris Bonaventure,Joe McKellar,Rémi Planès,Sébastien Nisole,Mary Arnaud-Arnould,Olivier Moncorgé,Caroline Goujon +10 more
TL;DR: In this paper, the authors characterized in depth host cell responses against SARS-CoV-2 in primary human airway epithelia (HAE) and immortalized cell lines.
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Rapid generation of neutralizing antibody responses in COVID-19 patients.
Mehul S. Suthar,Matthew G. Zimmerman,Robert C. Kauffman,Grace Mantus,Susanne L. Linderman,Abigail Vanderheiden,Lindsay E. Nyhoff,Carl W. Davis,Seyi Adekunle,Maurizio Affer,Melanie A. Sherman,Stacian Reynolds,Hans Verkerke,David Alter,Jeannette Guarner,Janetta Bryksin,Michael Horwath,Connie M. Arthur,Natia Saakadze,Geoffrey H. Smith,Srilatha Edupuganti,Erin M. Scherer,Kieffer Hellmeister,Andrew Cheng,Juliet A. Morales,Andrew S. Neish,Sean R. Stowell,Filipp Frank,Eric A. Ortlund,Evan J. Anderson,Vineet D. Menachery,Nadine Rouphael,Aneesh Metha,David S. Stephens,Rafi Ahmed,John D. Roback,Jens Wrammert +36 more
TL;DR: The dynamics of antibody responses to the receptor-binding domain (RBD) of the spike protein and virus neutralization activity in 44 COVID-19 patients revealed the magnitude of RBD-specific IgG binding titers correlated strongly with viral neutralization.
References
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Jasper Fuk-Woo Chan,Shuofeng Yuan,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Hin Chu,Jin Yang,Fanfan Xing,Jieling Liu,Cyril C. Y. Yip,Rosana W.S. Poon,Hoi Wah Tsoi,Simon Kam Fai Lo,Kwok-Hung Chan,Vincent Kwok-Man Poon,Wan Mui Chan,Jonathan Daniel Ip,Jian Piao Cai,Vincent C.C. Cheng,Honglin Chen,Honglin Chen,Christopher K.M. Hui,Kwok-Yung Yuen +22 more
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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