SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.About:
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.read more
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Incidence, clinical characteristics and prognostic factor of patients with COVID-19: a systematic review and meta-analysis
TL;DR: This is the first evidence-based medicine research to explore the risk factors of prognosis in patients with COVID-19, which is helpful to identify early-stage patients with poor prognosis and adapt effective treatment.
Journal ArticleDOI
The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target.
Mohamed Abu-Farha,Thangavel Alphonse Thanaraj,Mohammad Qaddoumi,Anwar M. Hashem,Jehad Abubaker,Fahd Al-Mulla +5 more
TL;DR: The role of lipid metabolism in viral infection as well as the possibility of targeting lipid metabolism to interfere with the viral life cycle are discussed.
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A comparison of four serological assays for detecting anti-SARS-CoV-2 antibodies in human serum samples from different populations.
Ludivine Grzelak,Ludivine Grzelak,Sarah Temmam,Cyril Planchais,Caroline Demeret,Laura Tondeur,Christèle Huon,Florence Guivel-Benhassine,Isabelle Staropoli,Maxime Chazal,Jérémy Dufloo,Jérémy Dufloo,Delphine Planas,Julian Buchrieser,Maaran Michael Rajah,Maaran Michael Rajah,Rémy Robinot,Françoise Porrot,Mélanie Albert,Mélanie Albert,Kuang-Yu Chen,Bernadette Crescenzo-Chaigne,Flora Donati,Flora Donati,François Anna,Philippe Souque,Marion Gransagne,Jacques Bellalou,Mireille Nowakowski,Marija Backovic,Lila Bouadma,Lila Bouadma,Lucie Le Fevre,Quentin Le Hingrat,Quentin Le Hingrat,Diane Descamps,Diane Descamps,Annabelle Pourbaix,Cédric Laouénan,Cédric Laouénan,Jade Ghosn,Jade Ghosn,Yazdan Yazdanpanah,Yazdan Yazdanpanah,Camille Besombes,Nathalie Jolly,Sandrine Pellerin-Fernandes,Olivia Chény,Marie Noelle Ungeheuer,Guillaume Mellon,Pascal Morel,Simon Rolland,Félix A. Rey,Sylvie Behillil,Sylvie Behillil,Vincent Enouf,Vincent Enouf,Audrey Lemaitre,Marie Aude Créach,Stéphane Petres,Nicolas Escriou,Pierre Charneau,Arnaud Fontanet,Arnaud Fontanet,Bruno Hoen,Timothée Bruel,Marc Eloit,Hugo Mouquet,Olivier Schwartz,Sylvie van der Werf,Sylvie van der Werf +70 more
TL;DR: Four serological assays measuring anti–SARS-CoV-2 antibodies and their neutralizing activity in samples from individuals with severe and mild COVID-19 are compared and enabled a broad evaluation of SARS- CoV- 2 seroprevalence and antibody profiling in different subpopulations within one region.
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COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms.
TL;DR: In this article, the authors explore the pathobiological mechanisms of immunothrombosis and venous thromboemboli (VTE) in COVID-19.
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Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation
Xianding Deng,Miguel Garcia-Knight,Mir M. Khalid,Venice Servellita,Candace Wang,Mary Kate Morris,Alicia Sotomayor-Gonzalez,Dustin R. Glasner,Kevin Reyes,Amelia S. Gliwa,Nikitha P. Reddy,Claudia Sanchez San Martin,Scot Federman,Jing Cheng,Joanna Balcerek,Jordan E. Taylor,Jessica Streithorst,Steve Miller,G. Renuka Kumar,Bharath Sreekumar,Pei-Yi Chen,Ursula Schulze-Gahmen,Taha Y. Taha,Jennifer M. Hayashi,Camille R Siomoneau,Sarah McMahon,Peter V. Lidsky,Yinghong Xiao,Nicole M Green,Peera Hemarajata,Alex Espinosa,Chantha Kath,Monica Haw,John Bell,Jill K. Hacker,Carl L. Hanson,Debra A. Wadford,Carlos Anaya,Donna Ferguson,Liana F. Lareau,Phillip A. Frankino,Haridha Shivram,Stacia K. Wyman,Melanie Ott,Melanie Ott,Raul Andino,Charles Y. Chiu +46 more
TL;DR: A novel SARS-CoV-2 variant was identified by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California.
References
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Jasper Fuk-Woo Chan,Shuofeng Yuan,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Hin Chu,Jin Yang,Fanfan Xing,Jieling Liu,Cyril C. Y. Yip,Rosana W.S. Poon,Hoi Wah Tsoi,Simon Kam Fai Lo,Kwok-Hung Chan,Vincent Kwok-Man Poon,Wan Mui Chan,Jonathan Daniel Ip,Jian Piao Cai,Vincent C.C. Cheng,Honglin Chen,Honglin Chen,Christopher K.M. Hui,Kwok-Yung Yuen +22 more
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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