SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.About:
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.read more
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D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
Sophie M. C. Gobeil,Katarzyna Janowska,Shana McDowell,Katayoun Mansouri,Robert Parks,Kartik Manne,Victoria Stalls,Megan Kopp,Rory Henderson,Rory Henderson,Robert J. Edwards,Robert J. Edwards,Barton F. Haynes,Barton F. Haynes,Priyamvada Acharya,Priyamvada Acharya +15 more
TL;DR: In this article, the effects of the D614G mutation on a soluble S ectodomain construct were explored and the results elucidate SARS-CoV-2 conformational landscape and allostery and have implications for vaccine design.
Journal ArticleDOI
Human iPSC-Derived Cardiomyocytes , are Susceptible to SARS-CoV-2 Infection
Arun Sharma,Gustavo Garcia,Yizhou Wang,Jasmine T. Plummer,Kouki Morizono,Vaithilingaraja Arumugaswami,Clive N. Svendsen +6 more
TL;DR: It is shown that SARS-CoV-2 can infect hiPSC-CMs in vitro, establishing a model for elucidating infection mechanisms and potentially a cardiac-specific antiviral drug screening platform.
Journal ArticleDOI
COVID-19 and immunomodulation in IBD.
TL;DR: The current understanding of the pathophysiology of COVID-19 is reviewed with special reference to immune cell activation and the potential implications of these new insights for immunomodulation and biological therapy in IBD are discussed.
Posted Content
Network Medicine Framework for Identifying Drug Repurposing Opportunities for COVID-19
Deisy Morselli Gysi,Italo Faria do Valle,Marinka Zitnik,Asher Ameli,Xiao Gan,Onur Varol,Susan Dina Ghiassian,J. J. Patten,Robert A. Davey,Joseph Loscalzo,Albert-László Barabási +10 more
TL;DR: Three network-based drug repurposing strategies are deployed, relying on network proximity, diffusion, and AI-based metrics, allowing to rank all approved drugs based on their likely efficacy for COVID-19 patients, and aggregate all predictions, to arrive at 81 promising repurpose candidates.
Journal ArticleDOI
SARS-CoV-2 pathogenesis
Mart M. Lamers,Bart L. Haagmans +1 more
TL;DR: In this paper , the authors explore recent clinical and experimental advances regarding SARS-CoV-2 pathophysiology and discuss potential mechanisms behind acute respiratory distress syndrome (ARDS), specifically focusing on new insights obtained using novel technologies such as single-cell omics, organoid infection models and CRISPR screens.
References
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TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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