SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TLDR
It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.About:
This article is published in Cell.The article was published on 2020-04-16 and is currently open access. It has received 15362 citations till now. The article focuses on the topics: Proteases.read more
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Enhanced SARS-CoV-2 neutralization by dimeric IgA.
Zijun Wang,Julio C. C. Lorenzi,Frauke Muecksch,Shlomo Finkin,Charlotte Viant,Christian Gaebler,Melissa Cipolla,Hans-Heinrich Hoffmann,Thiago Y. Oliveira,Deena A. Oren,Victor A. Ramos,Lilian Nogueira,Eleftherios Michailidis,Davide F. Robbiani,Anna Gazumyan,Charles M. Rice,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +21 more
TL;DR: The authors found that dimeric IgA antibodies neutralized SARS-CoV-2 more effectively than their monomeric counterparts, and suggested that vaccines that induce dimeric igA antibodies at mucosal surfaces may be good candidates for protection against SARS, the virus that causes COVID-19.
Journal ArticleDOI
Vascular occlusion by neutrophil extracellular traps in COVID-19.
Moritz Leppkes,Jasmin Knopf,Elisabeth Naschberger,Aylin Lindemann,Jeeshan Singh,Irmgard Herrmann,Michael Stürzl,Léonie A N Staats,Aparna Mahajan,Christine Schauer,Anita N. Kremer,Simon Völkl,Kerstin Amann,Katja Evert,Christina Falkeis,Andreas Wehrfritz,Ralf J. Rieker,Arndt Hartmann,Andreas E. Kremer,Markus F. Neurath,Luis E. Muñoz,Georg Schett,Martin Herrmann +22 more
TL;DR: It is shown that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels, and Histopathology of the lungs and other organs from CO VID-19 patients showed congestions of numerous micro- Vessels by aggregated NETs associated with endothelial damage.
Journal ArticleDOI
Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis.
Jin-Wen Song,Sin Man Lam,Xing Fan,Wen-Jing Cao,Si Yu Wang,He Tian,Gek Huey Chua,Chao Zhang,Fan Ping Meng,Zhe Xu,Jun Liang Fu,Lei Huang,Peng Xia,Tao Yang,Shaohua Zhang,Bowen Li,Tian Jun Jiang,Raoxu Wang,Zehua Wang,Ming Shi,Ji Yuan Zhang,Fu-Sheng Wang,Guanghou Shui +22 more
TL;DR: It is suggested that GM3-enriched exosomes may partake in pathological processes related to COVID-19 pathogenesis, and the largest repository on the plasma lipidome and metabolome distinct to CO VID-19 is presented.
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IL-6 in inflammation, autoimmunity and cancer.
TL;DR: IL-6 is a nexus for immune responses and disease and its role in vaccine selection and wound healing is under investigation.
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Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality.
Emil L. Fosbøl,Jawad H. Butt,Lauge Østergaard,Charlotte Andersson,Christian Selmer,Kristian Kragholm,Morten Schou,Matthew Phelps,Gunnar Gislason,Gunnar Gislason,Thomas A. Gerds,Christian Torp-Pedersen,Lars Køber +12 more
TL;DR: Findings do not support discontinuation of ACEI/ARB medications that are clinically indicated in the context of the COVID-19 pandemic, and prior use ofACEI/ARBs was not significantly associated with CO VID-19 diagnosis among patients with hypertension or with mortality or severe disease among patients diagnosed as having COIDs.
References
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Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.
TL;DR: The Molecular Evolutionary Genetics Analysis (Mega) software implements many analytical methods and tools for phylogenomics and phylomedicine and has additionally been upgraded to use multiple computing cores for many molecular evolutionary analyses.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI
A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.
Jasper Fuk-Woo Chan,Shuofeng Yuan,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Hin Chu,Jin Yang,Fanfan Xing,Jieling Liu,Cyril C. Y. Yip,Rosana W.S. Poon,Hoi Wah Tsoi,Simon Kam Fai Lo,Kwok-Hung Chan,Vincent Kwok-Man Poon,Wan Mui Chan,Jonathan Daniel Ip,Jian Piao Cai,Vincent C.C. Cheng,Honglin Chen,Honglin Chen,Christopher K.M. Hui,Kwok-Yung Yuen +22 more
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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