Shared genetic etiology between alcohol dependence and major depressive disorder.
Jerome C. Foo,Fabian Streit,Jens Treutlein,Stephan Ripke,Stephanie H. Witt,Jana Strohmaier,Franziska Degenhardt,Andreas J. Forstner,Per Hoffmann,Michael Soyka,Norbert Dahmen,Norbert Scherbaum,Norbert Wodarz,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Sven Cichon,Sven Cichon,Ulrich W. Preuss,Wolfgang Gaebel,Monika Ridinger,Sabine Hoffmann,Thomas G. Schulze,Wolfgang Maier,Peter Zill,Bertram Müller-Myhsok,Marcus Ising,Susanne Lucae,Markus M. Nöthen,Karl Mann,Falk Kiefer,Marcella Rietschel,Josef Frank +32 more
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TLDR
The findings replicate the reported genetic overlap between AD and MDD and also suggest the need for improved, rigorous phenotyping to identify true shared cross-disorder genetic factors.Citations
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Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy
Jerome C. Foo,Fabian Streit,Josef Frank,Stephanie H. Witt,Jens Treutlein,Bernhard T. Baune,Susanne Moebus,Karl-Heinz Jöckel,Andreas J. Forstner,Markus M. Nöthen,Markus M. Nöthen,Marcella Rietschel,Alexander Sartorius,Laura Kranaster +13 more
TL;DR: The findings indicate that ECT cohorts show an increased genetic burden for MD and are consistent with the hypothesis that treatment‐resistant MD patients represent a subgroup with an increase genetic risk for MD.
Journal ArticleDOI
Exploring Brain Derived Neurotrophic Factor and Cell Adhesion Molecules as Biomarkers for the Transdiagnostic Symptom Anhedonia in Alcohol Use Disorder and Comorbid Depression
L. A. Levchuk,Elise M. G. Meeder,Olga V. Roschina,Anton J. M. Loonen,Anastasiia S Boiko,Ekaterina V. Michalitskaya,E.V. Epimakhova,Innokentiy S. Losenkov,G. G. Simutkin,Nikolay A. Bokhan,Arnt F. A. Schellekens,Svetlana A. Ivanova +11 more
TL;DR: Investigating transdiagnostic biomarkers in AUD and depression co-morbidity suggests that peripheral levels of BDNF and NCAM might be reduced in AUD with and without comorbid mood disorder.
Journal ArticleDOI
Effect of vortioxetine in subjects with major depressive and alcohol use disorders: a 6-month retrospective analysis.
Marco Di Nicola,Marco Di Nicola,Maria Pepe,Isabella Panaccione,Lorenzo Moccia,Lorenzo Moccia,Luigi Dattoli,Marzia Molinaro,Gabriele Sani,Gabriele Sani,Luigi Janiri,Luigi Janiri,Roger S. McIntyre +12 more
TL;DR: Given its effectiveness on mood, cognition, and functioning, its good safety and tolerability profile, and low potential for abuse, vortioxetine could represent a valid pharmacological intervention in MDD + AUD patients as part of an integrated therapeutic-rehabilitation program.
Dissertation
Autobiographical memory and early-onset depression : insights from the environment, genetics and brain structure
TL;DR: The authors examined the cross-sectional and longitudinal relationships between overgeneral memory and depression and found that overgeneral AM to negative cues was associated with depressive symptoms and depressive symptoms three years later, thereby indicating temporal precedence.
Journal ArticleDOI
The phenomics and genetics of addictive and affective comorbidity in opioid use disorder.
TL;DR: In this article, the authors describe the prevalence and clinical significance of addictive and affective comorbidities as risk factors for OUD development as a basis for rational opioid prescribing and OUD treatment and to improve efforts to prevent the disorder.
References
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Journal Article
Is there a genetic relationship between alcoholism and depression
TL;DR: The Collaborative Study on the Genetics of Alcoholism (COGA) seeks to identify genes contributing to alcoholism and related traits (i.e., phenotypes), including depression as mentioned in this paper.
Journal ArticleDOI
The relationship between alcoholism and unipolar depression : a controlled family study
TL;DR: Comorbidity between the two disorders was more common than expected by chance, but excess comorbidities was preferentially mediated by non-familial factors.
Journal ArticleDOI
Genome-wide association discoveries of alcohol dependence.
Lingjun Zuo,Lingeng Lu,Yunlong Tan,Xinghua Pan,Yiqiang Cai,Xiaoping Wang,Jiang Hong,Chunlong Zhong,Fei Wang,Xiang Yang Zhang,Lauren A. Vanderlinden,Boris Tabakoff,Xingguang Luo +12 more
TL;DR: The most robust risk locus was the ADH cluster, and this conclusion will significantly contribute to the post-GWAS follow-up studies on alcohol dependence.
Journal ArticleDOI
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families
Manav Kapoor,Jen Chyong Wang,Leah Wetherill,Nhung Le,Sarah Bertelsen,Anthony L. Hinrichs,John P. Budde,Arpana Agrawal,Laura Almasy,Kathleen K. Bucholz,Danielle M. Dick,Oscar Harari,Xuei Xiaoling,Victor Hesselbrock,John Kramer,John I. Nurnberger,John P. Rice,Marc A. Schuckit,Jay A. Tischfield,Bernice Porjesz,Howard J. Edenberg,Laura J. Bierut,Tatiana Foroud,Alison Goate +23 more
TL;DR: This extended family based genome-wide cox-proportional hazards analysis identified several loci that might be associated with age at onset of AD, including an intergenic SNP, rs2168784 on chromosome 3 that showed strong evidence of association among regular drinkers.
Journal ArticleDOI
Specificity of familial vulnerability for alcoholism versus major depression in men.
Michael J. Lyons,Mark Schultz,Michael C. Neale,Kathleen T. Brady,Seth A. Eisen,Rosemary Toomey,Andrew Rhein,Stephen V. Faraone,Ming T. Tsuang,Ming T. Tsuang +9 more
TL;DR: The data are most consistent with a mechanism of reciprocal causation, whereby MD increases risk for AD and AD increases risk of MD, and a model in which genetic and environmental influences on each disorder were correlated could not be definitively rejected.
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