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Open AccessJournal ArticleDOI

Genome-wide association for major depression through age at onset stratification: Major depressive disorder working group of the Psychiatric Genomics Consortium

Robert Power, +84 more
- 15 Feb 2017 - 
- Vol. 81, Iss: 4, pp 325-335
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TLDR
It is demonstrated that using additional phenotype data previously collected by genetic studies to tackle phenotypic heterogeneity in MDD can successfully lead to the discovery of genetic risk factor despite reduced sample size.
About: 
This article is published in Biological Psychiatry.The article was published on 2017-02-15 and is currently open access. It has received 150 citations till now. The article focuses on the topics: Major depressive disorder & Bipolar disorder.

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Microbial genome-wide association studies: lessons from human GWAS

Robert Power, +4 more
- 01 Jan 2017 - 
TL;DR: The methodologies of GWAS are outlined, the current state of the field of microbial GWAS, and how lessons from human GWAS can direct the future of this field are outlined.
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Machine learning in major depression: From classification to treatment outcome prediction.

Shuang Gao, +3 more
- 01 Nov 2018 - 
TL;DR: Exploring translational biomarkers of mood disorders based on machine learning is in pressing need, though it is challenging, but with great potential to improve the understanding of these disorders.
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The use of polygenic risk scores to identify phenotypes associated with genetic risk of schizophrenia: Systematic review.

Sumit Mistry, +4 more
- 10 Nov 2017 - 
TL;DR: Overall, SZ-PRS was associated with increased risk for psychiatric disorders such as depression and bipolar disorder, lower performance IQ and negative symptoms, and a framework is proposed to guide robust reporting of PRS associations in the future.
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Adolescent and adult differences in major depression symptom profiles

Frances Rice, +7 more
- 15 Jan 2019 - 
TL;DR: Differences in how depression presents in adolescents and adults may be consistent with different pathophysiological mechanisms.
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Characterizing Developmental Trajectories and the Role of Neuropsychiatric Genetic Risk Variants in Early-Onset Depression

Frances Rice, +6 more
- 01 Mar 2019 - 
TL;DR: Evidence of distinct depressive trajectories, primarily distinguished by age at onset, is demonstrated, consistent with emerging evidence for a neurodevelopmental component in some cases of depression and suggest that the presence of this component is more likely when the onset of depression is very early.
References
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Reference EntryDOI

Diagnostic and Statistical Manual of Mental Disorders

Janet B. W. Williams
Journal ArticleDOI

PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

Shaun Purcell, +17 more
- 01 Sep 2007 - 
TL;DR: This work introduces PLINK, an open-source C/C++ WGAS tool set, and describes the five main domains of function: data management, summary statistics, population stratification, association analysis, and identity-by-descent estimation, which focuses on the estimation and use of identity- by-state and identity/descent information in the context of population-based whole-genome studies.
Journal ArticleDOI

The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).

Ronald C. Kessler, +8 more
- 18 Jun 2003 - 
TL;DR: Notably, major depressive disorder is a common disorder, widely distributed in the population, and usually associated with substantial symptom severity and role impairment, and while the recent increase in treatment is encouraging, inadequate treatment is a serious concern.
Journal ArticleDOI

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Theo Vos, +363 more
- 15 Dec 2012 - 
TL;DR: Prevalence and severity of health loss were weakly correlated and age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010, but population growth and ageing have increased YLD numbers and crude rates over the past two decades.
Journal ArticleDOI

The Genotype-Tissue Expression (GTEx) project

John T. Lonsdale, +129 more
- 29 May 2013 - 
TL;DR: The Genotype-Tissue Expression (GTEx) project is described, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.
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