Shared genetic etiology between alcohol dependence and major depressive disorder.
Jerome C. Foo,Fabian Streit,Jens Treutlein,Stephan Ripke,Stephanie H. Witt,Jana Strohmaier,Franziska Degenhardt,Andreas J. Forstner,Per Hoffmann,Michael Soyka,Norbert Dahmen,Norbert Scherbaum,Norbert Wodarz,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Sven Cichon,Sven Cichon,Ulrich W. Preuss,Wolfgang Gaebel,Monika Ridinger,Sabine Hoffmann,Thomas G. Schulze,Wolfgang Maier,Peter Zill,Bertram Müller-Myhsok,Marcus Ising,Susanne Lucae,Markus M. Nöthen,Karl Mann,Falk Kiefer,Marcella Rietschel,Josef Frank +32 more
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TLDR
The findings replicate the reported genetic overlap between AD and MDD and also suggest the need for improved, rigorous phenotyping to identify true shared cross-disorder genetic factors.Citations
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Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy
Jerome C. Foo,Fabian Streit,Josef Frank,Stephanie H. Witt,Jens Treutlein,Bernhard T. Baune,Susanne Moebus,Karl-Heinz Jöckel,Andreas J. Forstner,Markus M. Nöthen,Markus M. Nöthen,Marcella Rietschel,Alexander Sartorius,Laura Kranaster +13 more
TL;DR: The findings indicate that ECT cohorts show an increased genetic burden for MD and are consistent with the hypothesis that treatment‐resistant MD patients represent a subgroup with an increase genetic risk for MD.
Journal ArticleDOI
Exploring Brain Derived Neurotrophic Factor and Cell Adhesion Molecules as Biomarkers for the Transdiagnostic Symptom Anhedonia in Alcohol Use Disorder and Comorbid Depression
L. A. Levchuk,Elise M. G. Meeder,Olga V. Roschina,Anton J. M. Loonen,Anastasiia S Boiko,Ekaterina V. Michalitskaya,E.V. Epimakhova,Innokentiy S. Losenkov,G. G. Simutkin,Nikolay A. Bokhan,Arnt F. A. Schellekens,Svetlana A. Ivanova +11 more
TL;DR: Investigating transdiagnostic biomarkers in AUD and depression co-morbidity suggests that peripheral levels of BDNF and NCAM might be reduced in AUD with and without comorbid mood disorder.
Journal ArticleDOI
Effect of vortioxetine in subjects with major depressive and alcohol use disorders: a 6-month retrospective analysis.
Marco Di Nicola,Marco Di Nicola,Maria Pepe,Isabella Panaccione,Lorenzo Moccia,Lorenzo Moccia,Luigi Dattoli,Marzia Molinaro,Gabriele Sani,Gabriele Sani,Luigi Janiri,Luigi Janiri,Roger S. McIntyre +12 more
TL;DR: Given its effectiveness on mood, cognition, and functioning, its good safety and tolerability profile, and low potential for abuse, vortioxetine could represent a valid pharmacological intervention in MDD + AUD patients as part of an integrated therapeutic-rehabilitation program.
Dissertation
Autobiographical memory and early-onset depression : insights from the environment, genetics and brain structure
TL;DR: The authors examined the cross-sectional and longitudinal relationships between overgeneral memory and depression and found that overgeneral AM to negative cues was associated with depressive symptoms and depressive symptoms three years later, thereby indicating temporal precedence.
Journal ArticleDOI
The phenomics and genetics of addictive and affective comorbidity in opioid use disorder.
TL;DR: In this article, the authors describe the prevalence and clinical significance of addictive and affective comorbidities as risk factors for OUD development as a basis for rational opioid prescribing and OUD treatment and to improve efforts to prevent the disorder.
References
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The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism.
Kenneth S. Kendler,Ellen E. Walters,Michael C. Neale,Ronald C. Kessler,Andrew C. Heath,Lindon J. Eaves +5 more
TL;DR: These results support the following hypotheses: each major risk factor domain influences comorbidity between these disorders in a distinct manner, and most of the genetic factors that influence vulnerability to alcoholism in women do not alter the risk for development of other common psychiatric disorders.
Journal ArticleDOI
Research Review: Polygenic methods and their application to psychiatric traits
Naomi R. Wray,Sang Hong Lee,Divya Mehta,Anna A. E. Vinkhuyzen,Frank Dudbridge,Christel M. Middeldorp,Christel M. Middeldorp +6 more
TL;DR: Genome-wide genotyping and sequencing studies are providing evidence that psychiatric disorders are truly polygenic, that is they have a genetic architecture of many genetic variants, including risk variants that are both common and rare in the population.
Journal ArticleDOI
The comorbidity of depression and substance use disorders.
TL;DR: The lack of unidirectional and consistent patterns of association for depression and substance use disorders indicates that multiple mechanisms of comorbidity are likely to be simultaneously active in this population.
Journal ArticleDOI
A genome-wide association study of alcohol dependence
Laura J. Bierut,Arpana Agrawal,Kathleen K. Bucholz,Kimberly F. Doheny,Cathy C. Laurie,Elizabeth W. Pugh,Sherri L. Fisher,Louis Fox,William Howells,Sarah Bertelsen,Anthony L. Hinrichs,Laura Almasy,Naomi Breslau,Robert Culverhouse,Danielle M. Dick,Howard J. Edenberg,Tatiana Foroud,Richard A. Grucza,Dorothy K. Hatsukami,Victor Hesselbrock,Eric O. Johnson,John Kramer,Robert F. Krueger,Samuel Kuperman,Michael T. Lynskey,Karl Mann,Rosalind J. Neuman,Markus M. Nöthen,John I. Nurnberger,Bernice Porjesz,Monika Ridinger,Nancy L. Saccone,Scott F. Saccone,Marc A. Schuckit,Jay A. Tischfield,Jen C. Wang,Marcella Rietschel,Alison Goate,John P. Rice +38 more
TL;DR: The dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence.
Journal ArticleDOI
Genome-wide association study of alcohol dependence.
Jens Treutlein,Sven Cichon,Monika Ridinger,Norbert Wodarz,Michael Soyka,Peter Zill,Wolfgang Maier,Rainald Moessner,Wolfgang Gaebel,Norbert Dahmen,Christoph Fehr,Norbert Scherbaum,Michael Steffens,Kerstin U. Ludwig,Josef Frank,H.-Erich Wichmann,Stefan Schreiber,Nico Dragano,Wolfgang H. Sommer,Fernando Leonardi-Essmann,Anbarasu Lourdusamy,Peter J. Gebicke-Haerter,Thomas F. Wienker,Patrick F. Sullivan,Markus M. Nöthen,Falk Kiefer,Rainer Spanagel,Karl Mann,Marcella Rietschel +28 more
TL;DR: This is the first GWAS and follow-up study to identify a genome-wide significant association in alcohol dependence and nine SNPs were located in genes that have been reported to be associated with alcohol dependence, including the CDH13 and ADH1C genes.
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