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Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Citations
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Journal ArticleDOI

Commensal bacteria make GPCR ligands that mimic human signalling molecules

Louis J. Cohen, +18 more
- 30 Aug 2017 - 
TL;DR: The results suggest that chemical mimicry of eukaryotic signalling molecules may be common among commensal bacteria and that manipulation of microbiota genes encoding metabolites that elicit host cellular responses represents a possible small-molecule therapeutic modality (microbiome-biosynthetic gene therapy).
Journal ArticleDOI

Compartmentalized and systemic control of tissue immunity by commensals

Yasmine Belkaid, +1 more
- 01 Jul 2013 - 
TL;DR: How resident commensals outside the gastrointestinal tract can control unique physiological niches and the potential implications of the dialog between these commensal and the host for the establishment of immune homeostasis, protective responses and tissue pathology are discussed.
Journal ArticleDOI

Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia.

Shigeo Hanada, +6 more
- 16 Nov 2018 - 
TL;DR: The literature on the interactions between host microbial communities and host defense is summarized, and how influenza, and other acute respiratory viral infections disrupt these interactions, thereby contributing to the pathogenesis of secondary bacterial infections is summarized.
Journal ArticleDOI

The respiratory tract microbiome and lung inflammation: a two-way street.

Gary B. Huffnagle, +2 more
- 01 Mar 2017 - 
TL;DR: Questions of future research include determining for specific lung diseases whether an altered lung microbiome initiates disease pathogenesis, promotes chronic inflammation, or is merely a marker of injury and inflammation, whether the lung microbiome can be manipulated therapeutically to change disease progression, and how the lung "ecosystem" collapses during pneumonia.
Journal ArticleDOI

Systematic Review: Adverse Events of Fecal Microbiota Transplantation.

Sinan Wang, +10 more
- 16 Aug 2016 - 
TL;DR: High quality randomized controlled trials are still needed for the more definite incidence of AEs of FMT, and both AEs and SAEs are not rare and should be carefully monitored throughout FMT.
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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A human gut microbial gene catalogue established by metagenomic sequencing

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QIIME allows analysis of high-throughput community sequencing data.

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A core gut microbiome in obese and lean twins

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