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Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Journal ArticleDOI

Human symbionts inject and neutralize antibacterial toxins to persist in the gut

Aaron G. Wexler, +13 more
- 29 Mar 2016 - 
TL;DR: It is reported that prominent human gut symbionts persist in the gut through continuous attack on their immediate neighbors, suggesting that gut microbes can determine their interactions through direct contact.
Journal ArticleDOI

International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.

Alasdair Scott, +17 more
- 01 Sep 2019 - 
TL;DR: In this paper, an international panel of experts delivered their opinions on key questions concerning the contribution of the human microbiome to carcinogenesis, including the relevance of dysbiosis/analtered gut, potential mechanisms of microbiota-induced carcinogenesis and future directions for research in the field.
Journal ArticleDOI

Severity of atopic disease inversely correlates with intestinal microbiota diversity and butyrate‐producing bacteria

Lotta Nylund, +7 more
- 01 Feb 2015 - 
TL;DR: The high diversity of microbiota and high abundance of butyrate‐producing bacteria were associated with milder Eczema, thus suggesting they have a role in alleviating symptoms of atopic eczema.
Journal ArticleDOI

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade.

Miles C. Andrews, +92 more
- 08 Jul 2021 - 
TL;DR: Profiling of gut microbiota demonstrated a significantly higher abundance of Bacteroides intestinalis in patients with toxicity, with upregulation of mucosal IL-1b in patient samples of colitis and in pre-clinical models, which offer potential new therapeutic angles for targeting toxicity to CICB.
Journal ArticleDOI

Integrative methods for analyzing big data in precision medicine

Vladimir Gligorijević, +2 more
- 01 Mar 2016 - 
TL;DR: This work outlines key challenges in precision medicine and present recent advances in data integration‐based methods to uncover personalized information from big data produced by various omics studies.
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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