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Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Journal ArticleDOI

Microbiome and skin diseases.

Patrick L.J.M. Zeeuwen, +3 more
- 01 Oct 2013 - 
TL;DR: The microbiome of normal human skin was found to have a high diversity and high interpersonal variation, and modulation of skin microbiota composition to restore host–microbiota homeostasis could be future strategies to treat or prevent disease.
Journal ArticleDOI

Rapidly expanding knowledge on the role of the gut microbiome in health and disease

María Carmen Cenit, +3 more
- 01 Oct 2014 - 
TL;DR: The different approaches used to characterize the human microbiome are described, current knowledge about the gut microbiome is reviewed, and how this knowledge could be used to improve human health by manipulating the gut microbiota is indicated.
Journal ArticleDOI

Cross-biome comparison of microbial association networks

Karoline Faust, +9 more
- 27 Oct 2015 - 
TL;DR: An under-appreciated role of evenness is suggested in shaping microbial association networks, and it is observed that soil microbial networks harbor proportionally fewer positive associations and are less densely interconnected than host-associated networks.
Journal ArticleDOI

The Placental Microbiome Varies in Association with Low Birth Weight in Full-Term Neonates

Jia Zheng, +5 more
- 17 Aug 2015 - 
TL;DR: It is novel in showing that the placental microbiome varies in association with low birth weight in full-term neonates, and indicates that Lactobacillus percentage was positively associated with birth weight.
Journal ArticleDOI

Prevotella diversity, niches and interactions with the human host

Adrian Tett, +5 more
- 28 May 2021 - 
TL;DR: Segata et al. as discussed by the authors reviewed the diversity, prevalence and potential connection of Prevotella spp. in the human host, highlighting how genomic methods and analysis have improved and should further help in framing their ecological role.
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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A human gut microbial gene catalogue established by metagenomic sequencing

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QIIME allows analysis of high-throughput community sequencing data.

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A core gut microbiome in obese and lean twins

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Diet rapidly and reproducibly alters the human gut microbiome

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