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Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Citations
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Journal ArticleDOI

A novel approach based on KATZ measure to predict associations of human microbiota with non-infectious diseases

Xing Chen, +4 more
- 23 Dec 2016 - 
TL;DR: A novel computational model of KATZ measure for Human Microbe‐Disease Association prediction (KATZHMDA) based on the assumption that functionally similar microbes tend to have similar interaction and non‐interaction patterns with noninfectious diseases, and vice versa is developed, which is the first tool for microbe‐disease association prediction.
Journal ArticleDOI

Gut Microbiota and Autism: Key Concepts and Findings

Helen T. Ding, +3 more
- 01 Feb 2017 - 
TL;DR: Evidence from animal models suggest that certain microbial shifts in the gut may produce changes consistent with the clinical picture of autism, with proposed mechanisms including toxin production, aberrations in fermentation processes/products, and immunological and metabolic abnormalities.
Journal ArticleDOI

Gut microbiota injury in allogeneic haematopoietic stem cell transplantation.

Yusuke Shono, +3 more
- 16 Feb 2018 - 
TL;DR: The potential role of intestinal flora in patients with haematopoietic malignancies who have received an allo-HSCT and in whether the microbiota affects clinical outcomes is discussed, including GVHD, relapse, infections and transplant-related mortality.
Journal ArticleDOI

Ancient genomic changes associated with domestication of the horse

Pablo Librado, +38 more
- 28 Apr 2017 - 
TL;DR: Early domestication selection patterns supporting the neural crest hypothesis are found, which provides a unified developmental origin for common domestic traits and reveals that Iron Age Scythian steppe nomads implemented breeding strategies involving no detectable inbreeding and selection for coat-color variation and robust forelimbs.
Journal ArticleDOI

Evaluating variation in human gut microbiota profiles due to DNA extraction method and inter-subject differences

Brett Wagner Mackenzie, +2 more
- 18 Feb 2015 - 
TL;DR: A systematic analysis of commonly used microbial DNA extraction methods, and significant sources of variation are identified, indicate that the largest portion of variation within the model was attributed to differences between subjects (biological variation).
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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