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Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Citations
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Journal ArticleDOI

Smoking cessation alters intestinal microbiota: insights from quantitative investigations on human fecal samples using FISH.

Luc Biedermann, +9 more
- 01 Sep 2014 - 
TL;DR: It is confirmed that intestinal microbiota composition in humans is influenced by smoking, and the characteristics of observed microbial shifts suggest a potential mechanistic association to alterations in body weight subsequent to smoking cessation.
Journal ArticleDOI

Pregnancy's stronghold on the vaginal microbiome

Marina Walther-Antonio, +11 more
- 04 Jun 2014 - 
TL;DR: Normal pregnancy is characterized by a microbiome that has low diversity and high stability, and comparative analyses showed that the vaginal microbiome during pregnancy is characterize by a marked dominance of Lactobacillus species in both Caucasian and African-American subjects.
Journal ArticleDOI

Medicines from microbiota

Bernat Olle
- 05 Apr 2013 - 
TL;DR: Five years after the launch of the Human Microbiome Project, several ventures are seeking to capitalize on the clinical promise of microbiome modulation, with some unique scientific, translational and regulatory challenges.
Journal ArticleDOI

Microbes and mucosal immune responses in asthma

Trevor T. Hansel, +2 more
- 09 Mar 2013 - 
TL;DR: An understanding of the role of microbes in the atopic march towards asthma, and in causing exacerbations of established asthma, provides the rationale for new specific treatments that can be assessed in clinical trials.
Journal ArticleDOI

Environment shapes the fecal microbiome of invasive carp species.

Jessica J. Eichmiller, +4 more
- 12 Aug 2016 - 
TL;DR: Despite the absence of a true stomach, invasive carp species exhibited a core microbiota that warrants future study, and environment is a dominant factor shaping the fecal bacterial communities of invasive carps.
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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A human gut microbial gene catalogue established by metagenomic sequencing

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A core gut microbiome in obese and lean twins

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