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Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Citations
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Journal ArticleDOI

The biogeography of polymicrobial infection.

Apollo Stacy, +4 more
- 01 Feb 2016 - 
TL;DR: The importance of considering spatial positioning in the study of polymicrobial infections is highlighted and targeting biogeography as a therapeutic strategy is discussed.
Journal ArticleDOI

The microbiome revolution

Martin J. Blaser
- 01 Oct 2014 - 
TL;DR: This Review series addresses how perturbations of the microbiota, such as through antibiotic use, influence its overall structure and function; how the microbiota contribute to immunity as well as to metabolic and inflammatory diseases.
Journal ArticleDOI

Beneficial modulation of the gut microbiota

Calum J. Walsh, +5 more
- 17 Nov 2014 - 
TL;DR: A variety of options are highlighted, including the use of changes in diet, prebiotics, antimicrobial‐based intervention, probiotics and faecal microbiota transplantation, and their relative merits with respect to modulating the intestinal community in a beneficial way are discussed.
Journal ArticleDOI

Social behavior shapes the chimpanzee pan-microbiome

Andrew H. Moeller, +5 more
- 01 Jan 2016 - 
TL;DR: It is shown that social behavior generates a pan-microbiome, preserving microbial diversity across evolutionary time scales and contributing to the evolution of host species–specific gut microbial communities.
Journal ArticleDOI

Modulators of mercury risk to wildlife and humans in the context of rapid global change

Collin A. Eagles-Smith, +7 more
- 01 Mar 2018 - 
TL;DR: This paper examines the role that key extrinsic and intrinsic drivers play on several aspects of Hg risk to humans and organisms in the environment, and addresses how the adverse health effects of HG in humans and wildlife are modulated by a range of extrinso- intrinsic drivers within the context of rapid global change.
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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