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Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Journal ArticleDOI

Network succession reveals the importance of competition in response to emulsified vegetable oil amendment for uranium bioremediation.

Ye Deng, +10 more
- 01 Jan 2016 - 
TL;DR: The modified random matrix theory-based network approach was modified to discern network succession in groundwater microbial communities in response to emulsified vegetable oil (EVO) amendment for uranium bioremediation, providing mechanistic understanding of the decreased phylogenetic diversity during environmental perturbations.
Journal ArticleDOI

Bacterial species involved in the conversion of dietary flavonoids in the human gut

Annett Braune, +1 more
- 10 Mar 2016 - 
TL;DR: Information is summarized on the so far identified human intestinal flavonoid-converting bacterial species and strains as well as their enzymes catalyzing the underlying reactions to increase the currently limited knowledge in this field.
Journal ArticleDOI

Frequent Replenishment Sustains the Beneficial Microbiome of Drosophila melanogaster

Jessamina E. Blum, +3 more
- 31 Dec 2013 - 
TL;DR: It is reported that establishment and maintenance of the Drosophila melanogaster microbiome depend on ingestion of bacteria, and one member of the microbiome, Lactobacillus plantarum, protects the fly from intestinal pathogens, suggesting that the microbiota can promote salubrious effects for the host.
Journal ArticleDOI

Higher Fecal Short-Chain Fatty Acid Levels Are Associated with Gut Microbiome Dysbiosis, Obesity, Hypertension and Cardiometabolic Disease Risk Factors

Jacobo de la Cuesta-Zuluaga, +8 more
- 27 Dec 2018 - 
TL;DR: Higher SCFA excretion was associated with evidence of gut dysbiosis, gut permeability, excess adiposity, and cardiometabolic risk factors, and studies assessing both fecal and circulating SCFAs are needed.
Journal ArticleDOI

The microbiome of aseptically collected human breast tissue in benign and malignant disease

Tina J. Hieken, +13 more
- 03 Aug 2016 - 
TL;DR: This work confirms the existence of a distinct breast microbiome and differences between the breast tissue microbiome in benign and malignant disease, and identifies distinct microbial communities in breast tissues from women with cancer as compared to women with benign breast disease.
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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A core gut microbiome in obese and lean twins

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