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Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Citations
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Journal ArticleDOI

Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract

Melis N. Anahtar, +23 more
- 19 May 2015 - 
TL;DR: This study proposes a mechanism by which cervicovaginal microbiota impact genital inflammation and thereby might affect a woman's reproductive health, including her risk of acquiring HIV.
Journal ArticleDOI

Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes.

Stefania Magnusdottir, +3 more
- 20 Apr 2015 - 
TL;DR: This work presents the first comprehensive assessment of the B-vitamin synthesis capabilities of the human gut microbiota, and proposes that in addition to diet, the gut microbiota is an important source of B- vitamins, and that changes in the Gut microbiota composition can severely affect the authors' dietary B-Vitamin requirements.
Journal ArticleDOI

Bacterial colonization factors control specificity and stability of the gut microbiota

S. Melanie Lee, +5 more
- 19 Sep 2013 - 
TL;DR: These findings reveal that intestinal Bacteroides have evolved species-specific physical interactions with the host that mediate stable and resilient gut colonization, and the CCF system represents a novel molecular mechanism for symbiosis.
Journal ArticleDOI

Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis.

Roman M. Stilling, +2 more
- 01 Jan 2014 - 
TL;DR: It is suggested that gut‐microbial products can affect chromatin plasticity within their host's brain that in turn leads to changes in neuronal transcription and eventually alters host behaviour, and that the microbiota itself may be viewed as an epigenetic entity.
Book ChapterDOI

Advancing our understanding of the human microbiome using QIIME

Jose A. Navas-Molina, +17 more
- 01 Jan 2013 - 
TL;DR: This chapter demonstrates the use of the QIIME pipeline to analyze microbial communities obtained from several sites on the bodies of transgenic and wild-type mice, as assessed using 16S rRNA gene sequences generated on the Illumina MiSeq platform.
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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A human gut microbial gene catalogue established by metagenomic sequencing

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QIIME allows analysis of high-throughput community sequencing data.

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- 11 Apr 2010 - 

A core gut microbiome in obese and lean twins

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- 22 Jan 2009 - 

Diet rapidly and reproducibly alters the human gut microbiome

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An obesity-associated gut microbiome with increased capacity for energy harvest

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