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Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Journal ArticleDOI

Preservation Methods Differ in Fecal Microbiome Stability, Affecting Suitability for Field Studies.

Se Jin Song, +7 more
TL;DR: The results provide the most comprehensive view to date of storage effects on stool and provide a paradigm for the future studies of other sample types that will be required to provide a global view of microbial diversity and its interaction among humans, animals, and the environment.
Journal ArticleDOI

Functions of the skin microbiota in health and disease.

James A. Sanford, +1 more
- 30 Nov 2013 - 
TL;DR: Recent findings of the interactions of skin microbial communities with host immunity are reviewed, and the role that dysbiosis of these communities plays in diseases of the skin is discussed.
Journal ArticleDOI

Metagenomics meets time series analysis: Unraveling microbial community dynamics

Karoline Faust, +8 more
- 01 Jun 2015 - 
TL;DR: The recent increase in the number of microbial time series studies offers new insights into the stability and dynamics of microbial communities, from the world's oceans to human microbiota as discussed by the authors, which can reveal periodic patterns, help to build predictive models or quantify irregularities that make community behavior unpredictable.
Journal ArticleDOI

Human genetic variation and the gut microbiome in disease.

Andrew Brantley Hall, +2 more
- 21 Aug 2017 - 
TL;DR: A number of recent findings support the hypothesis that certain host genetic variants predispose an individual towards microbiome dysbiosis, a condition in which the normal microbiome population structure is disturbed.
Journal ArticleDOI

Changes in Gut Microbiota in Rats Fed a High Fat Diet Correlate with Obesity-Associated Metabolic Parameters

Virginie Lecomte, +6 more
- 18 May 2015 - 
TL;DR: The observations suggest that propionate/acetate producing bacterial species may play a key role in the development of obesity in response to a HFD, and Lactobacillus intestinalis was the only species whose abundance was negatively correlated with change in body weight and fat mass.
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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A human gut microbial gene catalogue established by metagenomic sequencing

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QIIME allows analysis of high-throughput community sequencing data.

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A core gut microbiome in obese and lean twins

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Diet rapidly and reproducibly alters the human gut microbiome

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