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Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

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Citations
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Journal ArticleDOI

Signatures of early frailty in the gut microbiota.

Matthew A. Jackson, +8 more
- 29 Jan 2016 - 
TL;DR: There was a striking negative association between frailty and gut microbiota diversity, underpinned by specific taxonomic associations that represent targets for diagnostic surveillance, or for intervention studies to improve vitality in ageing.
Journal ArticleDOI

Structure and function of the human skin microbiome

Nina N. Schommer, +1 more
- 01 Dec 2013 - 
TL;DR: The present understanding of the function of microbe-host interactions on the skin is summarized and some unique features that distinguish skin commensal organisms from pathogenic microbes are highlighted.
Journal ArticleDOI

Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome

Kei E. Fujimura, +1 more
- 13 May 2015 - 
TL;DR: Evidence to date suggests that the airway and/or gut microbiome may represent fertile targets for prevention or management of allergic asthma and other diseases in which adaptive immune dysfunction is a prominent feature.
Journal ArticleDOI

Helminth Colonization Is Associated with Increased Diversity of the Gut Microbiota

Soo Ching Lee, +11 more
- 22 May 2014 - 
TL;DR: It is suggested that helminth-colonized individuals had greater species richness and number of observed OTUs with enrichment of Paraprevotellaceae, especially with Trichuris infection.
Journal ArticleDOI

Use of Metatranscriptomics in Microbiome Research

Stavros Bashiardes, +2 more
- 20 Apr 2016 - 
TL;DR: Some of the key metatranscriptomics strategies that are implemented to determine microbiota gene expression and its regulation are highlighted and discussed and the advantages and potential challenges associated with these approaches are discussed.
References
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Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
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A core gut microbiome in obese and lean twins

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