scispace - formally typeset
Open AccessJournal ArticleDOI

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, +253 more
- 14 Jun 2012 - 
- Vol. 486, Iss: 7402, pp 207-214
TLDR
The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: 
The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

read more

Content maybe subject to copyright    Report

Citations
More filters
Journal ArticleDOI

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

Alison Morris, +19 more
- 15 May 2013 - 
TL;DR: This study is the largest to examine composition of the lower respiratory tract microbiome in healthy individuals and the first to use the neutral model to compare the lung to the mouth, demonstrating that the lung microbiome does not derive entirely from the mouth.
Journal ArticleDOI

Characterization of the Gut Microbiome Using 16S or Shotgun Metagenomics.

Juan Jovel, +10 more
- 20 Apr 2016 - 
TL;DR: The two main approaches for analyzing the microbiome, 16S ribosomal RNA gene amplicons and shotgun metagenomics, are illustrated with analyses of libraries designed to highlight their strengths and weaknesses and several methods for taxonomic classification of bacterial sequences are discussed.
Journal ArticleDOI

The microbiome, cancer, and cancer therapy.

Beth A. Helmink, +4 more
- 01 Mar 2019 - 
TL;DR: The microbiome influences response to cancer therapy, including cancer immunotherapy, and also plays a role in therapeutic toxicity.

Supplementary Materials for Compartmentalized Control of Skin Immunity by Resident Commensals

Shruti Naik, +15 more
TL;DR: In mice, the skin microbiota have an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte function and this findings underscore the importance of the microbiota as a distinctive feature of tissue compartmentalization, and provide insight into mechanisms of immune system regulation by resident commensal niches in health and disease.
Journal ArticleDOI

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

Caitriona M. Guinane, +1 more
- 26 Mar 2013 - 
TL;DR: The manipulation of the gut microbiota is considered as a potential therapeutic option to treat chronic gastrointestinal disease and recently developed genomic and other tools used to study the gut microbiome are highlighted.
References
More filters
Journal ArticleDOI

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 
TL;DR: An overview of the analysis pipeline and links to raw data and processed output from the runs with and without denoising are provided.
Journal ArticleDOI

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Harry Sokol, +19 more
- 28 Oct 2008 - 
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI

Vaginal microbiome of reproductive-age women

Jacques Ravel, +14 more
- 15 Mar 2011 - 
TL;DR: The inherent differences within and between women in different ethnic groups strongly argues for a more refined definition of the kinds of bacterial communities normally found in healthy women and the need to appreciate differences between individuals so they can be taken into account in risk assessment and disease diagnosis.
Related Papers (5)

A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Qin, +52 more
- 04 Mar 2010 - 

QIIME allows analysis of high-throughput community sequencing data.

J. Gregory Caporaso, +27 more
- 11 Apr 2010 - 

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh, +14 more
- 22 Jan 2009 - 

Diet rapidly and reproducibly alters the human gut microbiome

Lawrence A. David, +12 more
- 23 Jan 2014 - 

An obesity-associated gut microbiome with increased capacity for energy harvest

Peter J. Turnbaugh, +5 more
- 21 Dec 2006 -