The Precision Medicine Initiative's All of Us Research Program: an agenda for research on its ethical, legal, and social issues
Pamela Sankar,Lisa S. Parker +1 more
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TLDR
It is concluded that PMI's All of Us Research Program represents a significant opportunity and obligation to identify, analyze, and respond to ELSI, and is called on the PMI to initiate a research program capable of taking on these challenges.About:
This article is published in Genetics in Medicine.The article was published on 2017-07-01 and is currently open access. It has received 204 citations till now. The article focuses on the topics: Health care & Research program.read more
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Neural systems underlying RDoC social constructs: An activation likelihood estimation meta-analysis
TL;DR: In this article , a series of coordinate-based meta-analyses using the activation likelihood estimate (ALE) method was performed on whole-brain coordinates reported from 864 fMRI contrasts using the NiMARE Python package, revealing convergence in medial prefrontal cortex, anterior cingulate cortex, posterior cingulated cortex, temporoparietal junction, bilateral insula, amygdala, fusiform gyrus, precuneus, and thalamus.
Journal ArticleDOI
African American mothers’ attitudes towards genetic testing in the InterGEN study
TL;DR: It is demonstrated that more favorable attitudes towards genetic testing correlated with higher levels of income, even when accounting for commonly cited negative predictors such as maternal age, education, country of origin, and religion.
Posted ContentDOI
Soft Windowing Application to Improve Analysis of High-throughput Phenotyping Data
Hamed Haselimashhadi,Jeremy Mason,Violeta Muñoz-Fuentes,Federico López-Gómez,K. O. Babalola,Elif F. Acar,Elif F. Acar,Vivek Kumar,Jacqui White,Ann M Flenniken,Ruairidh King,Ewan Straiton,John R. Seavitt,Angelina Gaspero,Arturo Garza,Audrey E. Christianson,Chih-Wei Hsu,Corey L. Reynolds,Denise G. Lanza,Isabel Lorenzo,Jennie R. Green,Juan Gallegos,Ritu Bohat,Rodney C. Samaco,Surabi Veeraragavan,Jong Kyoung Kim,Gregor Miller,Helmut Fuchs,Lillian Garrett,Lore Becker,Yeon Kyung Kang,Dave Clary,Soo Young Cho,Masaru Tamura,Nobuhiko Tanaka,Kyung Dong Soo,Alexandr Bezginov,Ghina Bou About,Marie-France Champy,Laurent Vasseur,Sophie Leblanc,Hamid Meziane,Mohammed Selloum,Patrick T. Reilly,Nadine Spielmann,Holger Maier,Valerie Gailus-Durner,Tania Sorg,Masuya Hiroshi,Obata Yuichi,Jason D. Heaney,Mary E Dickinson,Wurst Wolfgang,Glauco P. Tocchini-Valentini,Kevin C K Lloyd,Colin McKerlie,Je Kyung Seong,Herault Yann,Martin Hrabé de Angelis,Stephen D.M. Brown,Damian Smedley,Paul Flicek,Ann-Marie Mallon,Helen Parkinson,Terrence F. Meehan +64 more
TL;DR: “soft windowing” is introduced, a methodological approach that selects a window of time that includes the most appropriate controls for analysis that is generalisable and can benefit large-scale human phenomic projects such as the UK Biobank and the All of Us resources.
Journal ArticleDOI
Healthcare Fusion: An Innovative Framework for Health Information Management
TL;DR: In this paper , a healthcare fusion framework is proposed to achieve culturally and demographically relevant outcomes in precision medicine and population health, in ways that are convincing to stakeholders and investors, in addition, the proposed framework may prove relevant in informing governmental and private sector responses to sudden public health crises.
Book ChapterDOI
Patient Registries for Clinical Research
TL;DR: This chapter describes informatics principles and approaches relevant to the design and implementation of patient registries, with emphasis on the ingestion of clinical data and the role of patient Registries in research and learning health activities.
References
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Ethical Issues in Big Data Health Research: Currents in Contemporary Bioethics
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