C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
In vitro production of interleukin-1 receptor antagonist in chronic renal failure, CAPD and HD.
Brian J.G. Pereira,Debra D. Poutsiaka,Andrew J. King,James A. Strom,Geetha Narayan,Andrew S. Levey,Charles A. Dinarello +6 more
TL;DR: Cell content and production of IL-1 beta and IL-Ra by unstimulated and endotoxin- or IgG-stimulated peripheral blood mononuclear cells in undialyzed patients with chronic renal failure, patients on continuous ambulatory peritoneal dialysis (CAPD) and patients on chronic hemodialysis with reuse cuprophan membranes (HD) are studied.
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How interleukin-1β induces gouty arthritis.
TL;DR: The study by Joosten and coworkers goes a long way in providing the basis for the production of IL-1 induced by MSU, with the conclusion that more than MSU is needed to trigger an acute attack of gout.
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α1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1β responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes.
Peter A. Gottlieb,Aimon K. Alkanani,Aaron W. Michels,Eli C. Lewis,Leland Shapiro,Charles A. Dinarello,Danny Zipris +6 more
TL;DR: It is hypothesize that AAT may have a beneficial effect on T1D in recently diagnosed patients that is associated with downmodulation of IL-1β.
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Elevated Plasma Interleukin-1 Levels in Humans Following Ultraviolet Light Therapy for Psoriasis
TL;DR: It is demonstrated that UVB therapy induces circulating IL-1 and that this IL- 1 may originate from both keratinocyte and non-keratinocyte sources.
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Human leukocytic pyrogen test for detection of pyrogenic material in growth hormone produced by recombinant Escherichia coli.
TL;DR: Experiments demonstrate that the release of LP from human cells is a reliable indicator of the presence of materials that are pyrogenic for humans, and provide a probable explanation for the negative result from the LAL and rabbit pyrogen test in the initial lot of met-hGH which induced acute-phase reactions.