C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Production of fever and its effects on the host.
TL;DR: LP may have a much broader role to play in the inflammatory response than just mediating fever, and has a similarity (if not identity) to human lymphocyte activating factor (LAF) which is a monokine.
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35: Histone deacetylase inhibitors induce indoleamine 2, 3-dioxygenase and modulate dendritic cell functions
Pavan Reddy,Yaping Sun,Yoshinobu Maeda,Elizabeth Weisiger,Raimon Duran-Struuck,Charles A. Dinarello,James L.M. Ferrara +6 more
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Blocking interleukin-1 in sepsis
TL;DR: IL-1 receptor blockade has been studied in human disease including sepsis, and it appears that low doses of exogenously administered IL-1 may prove useful as a therapy, although clear-cut beneficial effects have not matched those demonstrated in animals.
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Theories of Fever From Antiquity to the Enlightenment
TL;DR: Theories on Fever From Antiquity to the Enlightenment is a compilation of seven essays that were delivered at a meeting of the Wellcome Institute for the History of Medicine in June 1980 and each expertly researched and clearly presented in the context of the specific theories of fevers.
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Dissociation of immunoregulatory function of blood monocytes from maturational state and expression of interleukin-1 in humans chronically infected with Schistosoma mansoni.
TL;DR: Overall, IL-1 production by PBMC stimulated with LPS or Staphylococcus albus was higher in infected individuals compared to uninfected controls and correlated with intensity of infection, but the intensity-related increase inIL-1 expression did not correlate with the maturational state or the immunoregulatory properties of the monocytes.