C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Protection from Inflammatory Organ Damage in a Murine Model of Hemophagocytic Lymphohistiocytosis Using Treatment with IL-18 Binding Protein
Laura Chiossone,Sandra Audonnet,Bruno Chetaille,Lionel Chasson,Lionel Chasson,Catherine Farnarier,Yael Berda-Haddad,Stefan Jordan,Ulrich H. Koszinowski,Marc Dalod,Marc Dalod,Karin Mazodier,Daniela Novick,Charles A. Dinarello,Eric Vivier,Gilles Kaplanski +15 more
TL;DR: Data suggest that IL-18BP is beneficial in an animal model of HLH and in combination with anti-infectious therapy may be a promising strategy to treat HLH patients.
Journal ArticleDOI
Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat
TL;DR: Findings are consistent with the concept that PGE2 is involved in the sequence of events underlying pyrogen fever and suggest that a fraction of P GE2 is bound to CSF protein, and this event may be important to the inactivation of the compound.
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Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein
Soohyun Kim,Tania Azam,Do-Young Yoon,Leonid L. Reznikov,Daniela Novick,Menachem Rubinstein,Charles A. Dinarello +6 more
TL;DR: The identification of E42 and K89 in the matureIL-18 peptide is consistent with previous modeling studies of IL-18 binding to IL- 18BP and explains the unusually high affinity of Il-18BP for IL-16.
Journal Article
Rabbit IL-1. Cloning, expression, biologic properties, and transcription during endotoxemia.
Joseph G. Cannon,Burton D. Clark,Paul T. Wingfield,U Schmeissner,C Losberger,Charles A. Dinarello,A. R. Shaw +6 more
TL;DR: Rabbit IL-1 alpha and beta were more pyrogenic in rabbits than human rIL-1 beta, whereas human riles were slightly more potent lymphocyte-activating factors, and recombinant rabbit proteins induced PGE and IL- 1 production from human PBMC in vitro.
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Interleukin 1 induces HIV-1 expression in chronically infected U1 cells: blockade by interleukin 1 receptor antagonist and tumor necrosis factor binding protein type 1.
Eric V. Granowitz,Bradford M. Saget,Bradford M. Saget,Monica Z. Wang,Monica Z. Wang,Charles A. Dinarello,Charles A. Dinarello,Paul R. Skolnik +7 more
TL;DR: IL-1 induces HIV-1 expression (via the IL-1RI) and NF-κB activity in U1 cells and these effects are blocked by IL- 1Ra and partially mediated by TNF.