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Charles A. Dinarello

Researcher at University of Colorado Denver

Publications -  1073
Citations -  152254

Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.

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Alarmins: Feel the Stress.

TL;DR: This article suggests a novel activity of these molecules as central initiators of sterile inflammation in response to nonlethal stress, a function the authors denote “stressorins,” and highlights the role of posttranslational modifications of stressorins as key regulators of their activity.
Journal Article

Induction of circulating IL-1 receptor antagonist by IFN treatment.

TL;DR: The induction of IL-1Ra may contribute to the antiviral, anti-inflammatory, and antiproliferative effects of IFN.
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The natural interleukin-1 receptor antagonist in tem and preterm parturition

TL;DR: Amniotic fluid contains the highest interleukin-1 receptor antagonist concentrations detected in any biologic fluid to date and exogenous anticytokine agents may be of value in the treatment of preterm labor.
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Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.

TL;DR: It is proposed that IL-32 is a marrow stromal marker that distinguishes patients with myelodysplastic syndrome and chronic myelomonocytic leukemia and may be a therapeutic target.