C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Production of tumor necrosis factor alpha and interleukin 1 beta by monocytic cells infected with human immunodeficiency virus.
TL;DR: The results suggest that HIV-infected monocytic cells may produce increased amounts of TNF alpha and IL-1 beta in response to stimuli that could be present in vivo.
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Production of Interleukin-1α, Interleukin-1β and Tumor Necrosis Factor by Human Mononuclear Cells Stimulated With Granulocyte-Macrophage Colony-Stimulating Factor
TL;DR: Human peripheral blood mononuclear cells were stimulated in vitro with recombinant human GM-CSF and production of IL-1 alpha,IL-1 beta, and tumor necrosis factor was measured by specific radioimmunoassays, suggesting that GM- CSF may play an important role in the host defense response by stimulating production of these cytokines.
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Role of Interleukin-l in Infectious Diseases
TL;DR: This review will focus on interleukin-l (IL-1) as a cytokine of primary and strategic importance to the outcome of infectious diseases, particularly those caused by bacteria.
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α-1-Antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood
Gregory B. Pott,Edward D. Chan,Edward D. Chan,Charles A. Dinarello,Leland Shapiro,Leland Shapiro +5 more
TL;DR: In vitro stimulation of whole blood from persons with a genetic AAT deficiency resulted in enhanced cytokine production compared with blood from healthy subjects, suggesting that endogenous AAT in blood contributes to the suppression of proinflammatory cytokine synthesis.
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In vitro production of IL 1β, IL 1α, TNF and IL 2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation
Stefan Endres,Stefan Endres,Joseph G. Cannon,Reza Ghorbani,Roy A. Dempsey,Stephen D. Sisson,Gerhard Lonnemann,Jos W. M. Van Der Meer,Sheldon M. Wolff,Charles A. Dinarello +9 more
TL;DR: The studies demonstrate that the amount of cytokine synthesized by PBMC is regulated independently for IL 1, TNF and IL 2, correlates forIL 1β and IL 1α, is intrinsic for low and high “producers”, and production of IL 1β increases with the use of oral cyclooxygenase inhibitors.