C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Patent
Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
TL;DR: In this article, the authors report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof, which relate to generating a construct of use in pharmaceutically acceptable compositions.
Journal ArticleDOI
Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects.
Dennis M. de Graaf,Dennis M. de Graaf,Martin Jaeger,Inge C.L. van den Munckhof,Rob ter Horst,Kiki Schraa,Jelle Zwaag,Matthijs Kox,Mayumi Fujita,Takeshi Yamauchi,Laura Mercurio,Stefania Madonna,Joost H.W. Rutten,Jacqueline de Graaf,Niels P. Riksen,Frank L. van de Veerdonk,Mihai G. Netea,Leo A. B. Joosten,Charles A. Dinarello,Charles A. Dinarello +19 more
TL;DR: It is concluded that a relative deficiency of the B cell product IL‐38 is associated with increased systemic inflammation in aging, cardiovascular and metabolic disease, and is consistent withIL‐38 as an anti‐inflammatory cytokine.
Patent
Interleukin-18 binding proteins, their preparation and use for blocking the activity of IL-18
TL;DR: In this article, the interleukin-18 binding proteins which are capable of binding IL-18 and modulating and/or blocking the activity of IL-17 are described.
Journal ArticleDOI
TNF receptor I is required for induction of macrophage heat shock protein 70.
Julie K. Heimbach,Leonid L. Reznikov,Casey M. Calkins,Thomas N. Robinson,Charles A. Dinarello,Alden H. Harken,Xianzhong Meng +6 more
TL;DR: It is demonstrated that TNfr-I is required for the synthesis of HSP70 in stressed Mphi by a TNF-independent mechanism and support an intracellular role for TNFR-I.
Journal ArticleDOI
IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis.
Michelle S M A Damen,Rabia Agca,Suzanne Holewijn,Jacqueline de Graaf,Jéssica Cristina dos Santos,Piet L. C. M. van Riel,Jaap Fransen,Marieke J H Coenen,Michael T. Nurmohamed,Mihai G. Netea,Charles A. Dinarello,Leo A. B. Joosten,Bas Heinhuis,Calin D. Popa +13 more
TL;DR: A functional effect of a promoter single-nucleotide polymorphism (SNP) in IL32 is shown on lipid profiles in RA patients and individuals, suggesting a possible protective role of this SNP against CVD.