C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat).
Antonio Furlan,Antonio Furlan,Valmen Monzani,Leonid L. Reznikov,Flavio Leoni,Gianluca Fossati,Daniela Modena,Paolo Mascagni,Charles A. Dinarello +8 more
TL;DR: It is concluded that dosing of 50 or 100 mg ITF2357 is safe in healthy humans and transiently but repeatedly reduces the production of proinflammatory cytokines without affecting production of anti inflammatory cytokines.
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Production of Cytokines by Peripheral Blood Monocytes/Macrophages Infected with Human Immunodeficiency Virus Type I (HIV-I)
Jean-Michel Molina,Ralf Schindler,Roberta Ferriani,Mamoru Sakaguchi,Edouard Vannier,Charles A. Dinarello,Jerome E. Groopman +6 more
TL;DR: HIV-1 infection does not appear to induce or alter cytokine production by mononuclear phagocytes, which retain the capacity to produce these cytokines after endotoxin stimulation.
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Interleukin-1 Blockade in Acute Decompensated Heart Failure: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study.
Benjamin W. Van Tassell,Nayef Abouzaki,Claudia Oddi Erdle,Salvatore Carbone,Cory R. Trankle,Ryan Melchior,Jeremy Turlington,Clint Thurber,Sanah Christopher,Dave L. Dixon,Daniel Taylor Fronk,Christopher S. Thomas,Scott W. Rose,Leo F. Buckley,Charles A. Dinarello,Giuseppe Biondi-Zoccai,Antonio Abbate +16 more
TL;DR: Interleukin-1 blockade with anakinra reduces the systemic inflammatory response in patients with ADHF and further studies are warranted to determine whether this anti-inflammatory effect translates into improved clinical outcomes.
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Interleukin-1 is released at sites of human cutaneous allergic reactions
Bruce S. Bochner,Ernest N. Charlesworth,Lawrence M. Lichtenstein,Claudia P. Derse,S Gillis,Charles A. Dinarello,Robert P. Schleimer +6 more
TL;DR: Bioactivity in chamber fluids from antigen-challenged sites of atopic subjects was significantly neutralized by an anti- IL-1 beta antiserum, although treatment with anti-IL-1 alpha and anti-ILS1 beta was needed for complete neutralization, IL- 1 released locally during cutaneous allergic reactions may contribute to IgE-dependent cutaneous inflammation.
Journal ArticleDOI
Human immunodeficiency virus does not induce interleukin-1, interleukin-6, or tumor necrosis factor in mononuclear cells.
J M Molina,David T. Scadden,C Amirault,Annie Woon,Edouard Vannier,Charles A. Dinarello,Jerome E. Groopman +6 more
TL;DR: These studies indicate that, in the absence of endotoxin, HIV-1, HIV -2, and HIV gp120 do not induce production of IL-1 beta, IL-6, or TNF-alpha by peripheral blood mononuclear cells.