C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal Article
Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.
TL;DR: In this paper, the authors found that the cytokine interleukin 1 (IL-1) is selectively cytotoxic for isolated human and rat pancreatic beta-cells and that macrophages present in the intra-islet mononuclear cell infiltrate in insulin-dependent diabetes mellitus may secrete monokines that could be important effector molecules in beta-cell destruction.
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Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β
TL;DR: It is demonstrated that endogenous IL-18 and IL-1β play a significant role in I/R-induced human myocardial injury and that inhibition of caspase 1 reduces the processing of endogenous precursors of IL- 18 and IL,1β and thereby prevents ischemia-induced myocardIAL dysfunction.
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Interleukin-1 stimulates prostaglandin biosynthesis by human amnion.
Roberto Romero,Scott K. Durum,Charles A. Dinarello,E. Oyarzun,John C. Hobbins,Murray D. Mitchell +5 more
TL;DR: Indomethacin blocked the effect of IL-1 in prostaglandin biosynthesis by human amnion, and Interleukin-1, a fever mediator, could serve as a signal for the initiation of labor in cases of intrauterine or systemic infection.
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Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.
TL;DR: In human peripheral blood mononuclear cells stimulated with IL-1 alpha, IL-4 markedly suppressedIL-1 beta production but enhanced IL- 1ra synthesis greater than 2-fold, suggesting IL- 4 may exert potent antiinflammatory effects on host responses to Gram-negative infections.
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Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans
Thomas Mandrup-Poulsen,Klaus Bendtzen,Jørn Nerup,Charles A. Dinarello,M. Svenson,Jens Høiriis Nielsen +5 more
TL;DR: It is suggested that Interleukin-1 may play an important role in the molecular mechanisms underlying autoimmune B-cell destruction leading to Type 1 (insulin-dependent) diabetes mellitus.