Charles A. Dinarello

TL;DR: In this article, the early events in the lung and LDLNs after pulmonary exposure to different physiochemical forms of beryllium were examined, and it was shown that soluble or crystalline forms of BeryllIUM induced alveolar macrophage death/release of IL-1α and DNA, enhanced migration of CD80hi DCs to the LDLNs, and sensitized HLA-DP2 transgenic mice after single low-dose exposures.

TL;DR: The results suggest that eosinophil subpopulations respond selectively to each form of IL-1, and specifically to the ability of mIL-1 to inhibit the oxidative response to suboptimal doses of phorbol myristate acetate (PMA).

TL;DR: The results indicate that increasing the amount of N‐fatty acids in the diet decreases the ability of blood mononuclear cells to synthesize IL‐1 in vitro, and it is suggested that the ameliorative effects of N-3 fatty acid dietary supplements in patients with hypersensitive diseases may be, in part, the result of decreased IL-1 production.

TL;DR: It is concluded that conditions that promote IL-37 expression attenuate morbidity to severe inflammatory challenge and sleep responses developed slowly over the 6 day recording period.

TL;DR: There were no significant changes in leptin levels over time in either group, nor were there significant differences between groups.