C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome.
TL;DR: Use of neutralizing antibodies to TNF or to IL-1 receptors have reduced the consequences of infection and inflammation, including lethal outcomes in animal models.
Journal ArticleDOI
A guiding map for inflammation
Mihai G. Netea,Frances R. Balkwill,Michel Chonchol,Fabio Cominelli,Marc Y. Donath,Evangelos J. Giamarellos-Bourboulis,Douglas T. Golenbock,Mark S. Gresnigt,Michael T. Heneka,Michael T. Heneka,Hal M. Hoffman,Richard S. Hotchkiss,Leo A. B. Joosten,Leo A. B. Joosten,Daniel L. Kastner,Martin Korte,Eicke Latz,Eicke Latz,Eicke Latz,Peter Libby,Thomas Mandrup-Poulsen,Alberto Mantovani,Kingston H. G. Mills,Kristen L. Nowak,Luke A. J. O'Neill,Peter Pickkers,Tom van der Poll,Paul M. Ridker,Joost Schalkwijk,David A. Schwartz,Britta Siegmund,Clifford J. Steer,Herbert Tilg,Jos W. M. van der Meer,Frank L. van de Veerdonk,Charles A. Dinarello,Charles A. Dinarello +36 more
TL;DR: A general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues is provided.
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Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.
James R. Zucali,Charles A. Dinarello,David J. Oblon,Mary Ann Gross,Lisa Anderson,Roy S. Weiner +5 more
TL;DR: It is concluded that monocytes produce IL-1, and that monocyte-derived IL- 1 induces fibroblasts to produce GM-CSA and PGE2.
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Sleep-promoting effects of endogenous pyrogen (interleukin-1)
TL;DR: It is concluded that the somnogenic activity of EP is not secondary to its pyrogenic activity, and that it is possible to induce prolonged increases in slow-wave sleep through infusion into the lateral cerebral ventricles of rabbits.
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The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense.
TL;DR: The interleukin 1 toll-like receptor superfamily is an expanding family of receptors, functioning as a rapid defense response to infection and injury, and possibly having other roles in human disease.