C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Ultrafiltration to reject human interleukin-1-inducing substances derived from bacterial cultures.
TL;DR: There is a considerable margin of safety with the ultrafiltration method and that it can be applied to clinical situations, based on the clinical model of bacterial contamination of fluid intended to be directly injected into humans.
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Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis: correlations with markers of inflammation and joint destruction.
TL;DR: The present findings indicate that increased levels of IL-1Ra, a natural antiinflammatory acute-phase protein, may reflect increased production and activity ofIL-1 in chronic polyarthritis.
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IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.
Cohen Idan,Rider Peleg,Voronov Elena,Tomas Martin,Tudor Cicerone,Wegner Mareike,Brondani Lydia,Freudenberg Marina,Mittler Gerhard,Ferrando-May Elisa,Charles A. Dinarello,Apte N. Ron,Schneider Robert +12 more
TL;DR: It is shown that IL-1α signaling after UV skin irradiation and DNA damage is important for triggering a sterile inflammatory cascade in vivo that contributes to efficient tissue repair and wound healing.
Journal Article
Antibodies to Domains II and III of the IL-1 Receptor Accessory Protein Inhibit IL-1β Activity But Not Binding: Regulation of IL-1 Responses Is Via Type I Receptor, Not the Accessory Protein
TL;DR: It is concluded that blocking IL-1RAcP inhibitsIL-1 signaling in D10S cells, domains-II and III may be involved in complex formation with IL-3RI, IL- 1RAcp is not regulated as is IL-2RI in the same cells, and IL-0 responsiveness is dependent on the expression of IL-4RI, not IL-oneRAcC.
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Interleukin-1β in human colostrum
C Munoz,C Munoz,Stefan Endres,J. W. M. Van Der Meer,Liana Schlesinger,Marianela Arevalo,Charles A. Dinarello +6 more
TL;DR: In this paper, colostrum from 9 healthy lactating women was analyzed for the presence of interleukin-1, IL-1α, and IL1β respectively, and tumour necrosis factor (TNF) were negligible.